1800405-30-4
1800405-30-4 structure
- Name: KL-1333(NQO1 activator 1)
- Chemical Name: NQO1 activator 1
- CAS Number: 1800405-30-4
- Molecular Formula: C14H12N2O2
- Molecular Weight: 240.26
- Catalog: Research Areas Others
- Create Date: 2019-09-11 16:41:03
- Modify Date: 2024-01-13 22:56:33
-
NQO1 activator 1 is an orally available NAD+ modulator. It reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation. Elevated NAD+ levels triggers the activation of SIRT1 and AMPK, and subsequently activates PGC-1α. NQO1 activator 1 improves energy metabolism and mitochondrial dysfunction in MELAS fibroblasts[1].
| Name | NQO1 activator 1 |
|---|
| Description | NQO1 activator 1 is an orally available NAD+ modulator. It reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation. Elevated NAD+ levels triggers the activation of SIRT1 and AMPK, and subsequently activates PGC-1α. NQO1 activator 1 improves energy metabolism and mitochondrial dysfunction in MELAS fibroblasts[1]. |
|---|---|
| Related Catalog | |
| Target |
NQO1[1] |
| References |
| Molecular Formula | C14H12N2O2 |
|---|---|
| Molecular Weight | 240.26 |