852679-76-6

852679-76-6 structure

Name: LY 541850
Chemical Name: LY 541850
CAS Number: 852679-76-6
Molecular Formula: C₉H₁₃NO₄
Molecular Weight: 199.20
Catalog: Signaling Pathways GPCR/G Protein mGluR
Create Date: 2019-09-07 12:12:16
Modify Date: 2024-01-10 10:58:28
LY 541850 is claimed from human ionotropic and metabotropic glutamate (mGlu) receptors expressed in non-neuronal cells. LY541850 is a selective orthosteric mGlu2 agonist and mGlu3 antagonist with IC50 values of 0.161 μM and 0.038 μM, respectively[1].

Name	LY 541850

Description	LY 541850 is claimed from human ionotropic and metabotropic glutamate (mGlu) receptors expressed in non-neuronal cells. LY541850 is a selective orthosteric mGlu2 agonist and mGlu3 antagonist with IC50 values of 0.161 μM and 0.038 μM, respectively[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> mGluR Research Areas >> Neurological Disease
Target	mGluR2:0.161 μM (IC50) mGluR3:1.05 μM (IC50)
In Vivo	LY 541850 (intraperitoneal injection; 10 mg/kg-300 mg/kg; 15 min prior) induces a concentration-dependent inhibition of the TAP evoked fEPSPs in CA1-SLM in 10-16 week old (EC50 42 nM) in CD-1 mice[1]. LY 541850 (intraperitoneal injection; 10 mg/kg-300 mg/kg; 30 min prior) reduces the increased locomotor activity of phencyclidine and amphetamine in a dose-dependent manner in male ICR mice[1].
References	[1]. Hanna L, et al. Differentiating the roles of mGlu2 and mGlu3 receptors using LY541850, an mGlu2 agonist/mGlu3 antagonist. Neuropharmacology. 2013 Mar;66:114-21.

Molecular Formula	C₉H₁₃NO₄
Molecular Weight	199.20