191672-52-3
191672-52-3 structure
- Name: CS-003 Free base
- Chemical Name: CS-003 Free base
- CAS Number: 191672-52-3
- Molecular Formula: C34H38Cl2N2O6S
- Molecular Weight: 673.65
- Catalog: Signaling Pathways GPCR/G Protein Neurokinin Receptor
- Create Date: 2019-09-07 11:57:19
- Modify Date: 2024-01-12 10:43:50
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CS-003 Free base (CS-003), a triple tachykinin receptor antagonist, shows high affinities for human (Neurokinin) NK1, NK2 and NK3 receptors with Ki values of 2.3 nM, 0.54 nM and 0.74 nM, respectively. CS-003 Free base (CS-003) has therapeutic efficacy on respiratory diseases associated with neurokinins.
| Name | CS-003 Free base |
|---|
| Description | CS-003 Free base (CS-003), a triple tachykinin receptor antagonist, shows high affinities for human (Neurokinin) NK1, NK2 and NK3 receptors with Ki values of 2.3 nM, 0.54 nM and 0.74 nM, respectively. CS-003 Free base (CS-003) has therapeutic efficacy on respiratory diseases associated with neurokinins. |
|---|---|
| Related Catalog | |
| Target |
NK1:2.3 nM (Ki) NK2:0.54 nM (Ki) NK3:0.74 nM (Ki) |
| In Vitro | CS-003 (0.01-10 μM; 24 hours) inhibits NK1, NK2 or NK3 induced inositol phosphate formation in a concentration-dependent manner with pA2 values of 8.7, 9.4 and 9.5 μM, respectively[1]. |
| In Vivo | CS-003 (intravenous injection; 0.01-3.0 mg/kg; 5 min before neurokinin A/B/C injection) inhibits substance P-induced tracheal vascular hyperpermeability, neurokinin A- and neurokinin B-induced bronchoconstriction with ID50 values of 0.13, 0.040 and 0.063 mg/kg, respectively[1]. |
| References |
| Molecular Formula | C34H38Cl2N2O6S |
|---|---|
| Molecular Weight | 673.65 |