1293281-49-8

1293281-49-8 structure

Name: Seltorexant
Chemical Name: Seltorexant
CAS Number: 1293281-49-8
Molecular Formula: C₂₁H₂₂FN₇O
Molecular Weight: 407.44
Catalog: Signaling Pathways GPCR/G Protein Orexin Receptor (OX Receptor)
Create Date: 2019-08-04 15:01:59
Modify Date: 2024-01-08 12:31:47
Seltorexant (JNJ-42847922) is an orally active, high-affinity, and selective OX2R antagonist (pKi values of 8.0 and 8.1 for human and rat OX2R). Seltorexant (JNJ-42847922) crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain[1].

Name	Seltorexant

Description	Seltorexant (JNJ-42847922) is an orally active, high-affinity, and selective OX2R antagonist (pKi values of 8.0 and 8.1 for human and rat OX2R). Seltorexant (JNJ-42847922) crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Orexin Receptor (OX Receptor) Research Areas >> Neurological Disease
Target	pKi: 8.0 (human OX2R), 8.1 (rat OX2R)[1]
References	[1]. Bonaventure P, et al. Characterization of JNJ-42847922, a Selective Orexin-2 Receptor Antagonist, as a Clinical Candidate for the Treatment of Insomnia. J Pharmacol Exp Ther. 2015 Sep;354(3):471-82.

Molecular Formula	C₂₁H₂₂FN₇O
Molecular Weight	407.44