1127308-52-4

1127308-52-4 structure

1127308-52-4 structure

Name: ROCK inhibitor-2
Chemical Name: ROCK inhibitor-2
CAS Number: 1127308-52-4
Molecular Formula: C₂₁H₂₀N₂O₂
Molecular Weight: 332.40
Catalog: Signaling Pathways Cell Cycle/DNA Damage ROCK
Create Date: 2019-06-29 09:02:05
Modify Date: 2024-01-06 10:10:59
ROCK inhibitor-2 is a selective dual ROCK1 and ROCK2 inhibitor with IC50s of 17 nM and 2 nM, respectively[1].

Name	ROCK inhibitor-2

Description	ROCK inhibitor-2 is a selective dual ROCK1 and ROCK2 inhibitor with IC50s of 17 nM and 2 nM, respectively[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Cell Cycle/DNA Damage >> ROCK Research Areas >> Inflammation/Immunology Signaling Pathways >> Stem Cell/Wnt >> ROCK Signaling Pathways >> TGF-beta/Smad >> ROCK
Target	ROCK1:17 nM (IC50) ROCK2:2 nM (IC50)
References	[1]. Hobson AD, et al. Identification of Selective Dual ROCK1 and ROCK2 Inhibitors Using Structure-Based DrugDesign. J Med Chem. 2018 Dec 27;61(24):11074-11100.

Molecular Formula	C₂₁H₂₀N₂O₂
Molecular Weight	332.40