2313524-95-5

2313524-95-5 structure

Name: BuChE-IN-TM-10
Chemical Name: BuChE-IN-TM-10
CAS Number: 2313524-95-5
Molecular Formula: C₃₂H₃₈N₂O₃
Molecular Weight: 498.66
Catalog: Signaling Pathways Neuronal Signaling AChE
Create Date: 2019-06-29 22:18:05
Modify Date: 2024-02-04 10:22:26
BuChE-IN-TM-10 (TM-10) is a potent butyrylcholinesterase (BuChE) inhibitor, with an IC50 of 8.9 nM. BuChE inhibitor 1 inhibits and disaggregates self-induced Aβ aggregation, exhibiting potent antioxidant activity and good blood-brain barrier (BBB) penetration. Has potential to treat Alzheimer’s disease[1].

Name	BuChE-IN-TM-10

Description	BuChE-IN-TM-10 (TM-10) is a potent butyrylcholinesterase (BuChE) inhibitor, with an IC50 of 8.9 nM. BuChE inhibitor 1 inhibits and disaggregates self-induced Aβ aggregation, exhibiting potent antioxidant activity and good blood-brain barrier (BBB) penetration. Has potential to treat Alzheimer’s disease[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> AChE
Target	IC50: 8.9 nM (BuChE)[1].
References	[1]. Sang Z, et al. Design, Synthesis, and Evaluation of Novel Ferulic Acid Derivatives as Multi-Target-Directed Ligands for the Treatment of Alzheimer's Disease. ACS Chem Neurosci. 2019 Feb 20;10(2):1008-1024.

Molecular Formula	C₃₂H₃₈N₂O₃
Molecular Weight	498.66