244021-67-8

244021-67-8 structure
244021-67-8 structure
  • Name: Indirubin-5-sulfonate
  • Chemical Name: Indirubin-5-sulfonate
  • CAS Number: 244021-67-8
  • Molecular Formula: C16H10N2O5S
  • Molecular Weight: 342.33
  • Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
  • Create Date: 2019-06-01 19:50:56
  • Modify Date: 2024-01-10 18:34:58
  • Indirubin-5-sulfonate is a cyclin-dependent kinase (CDK) inhibitor, with IC50 values of 55 nM, 35 nM, 150 nM, 300 nM and 65 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK4/cyclin D1, and CDK5/p35, respectively[1]. Indirubin-5-sulfonate also shows inhibitory activity against GSK-3β[2].

Name Indirubin-5-sulfonate
Description Indirubin-5-sulfonate is a cyclin-dependent kinase (CDK) inhibitor, with IC50 values of 55 nM, 35 nM, 150 nM, 300 nM and 65 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK4/cyclin D1, and CDK5/p35, respectively[1]. Indirubin-5-sulfonate also shows inhibitory activity against GSK-3β[2].
Related Catalog
Target

Cdk1/cyclin B:55 nM (IC50)

cdk2/cyclin A:35 nM (IC50)

CDK2/cyclinE:150 nM (IC50)

Cdk4/cyclin D1:300 nM (IC50)

CDK5/p35:65 nM (IC50)

GSK-3β

References

[1]. Hoessel R, et al. Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases. Nat Cell Biol. 1999 May;1(1):60-7.

[2]. Leclerc S, et al. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors? J Biol Chem. 2001 Jan 5;276(1):251-60.

Molecular Formula C16H10N2O5S
Molecular Weight 342.33