1421448-26-1

1421448-26-1 structure

Name: GN 44028
Chemical Name: GN44028
CAS Number: 1421448-26-1
Molecular Formula: C₁₈H₁₅N₃O₂
Molecular Weight: 305.33
Catalog: Signaling Pathways Metabolic Enzyme/Protease HIF/HIF Prolyl-Hydroxylase
Create Date: 2019-06-01 16:53:56
Modify Date: 2024-01-09 12:35:26
GN44028 is a hypoxia inducible factor (HIF)-1 inhibitor, with an IC50 of 14 nM. GN44028 inhibits hypoxia-induced HIF-1α transcriptional activity without suppressing HIF-1α mRNA expression, HIF-1α protein accumulation, or HIF-1α/HIF-1β heterodimerization[1].

Name	GN44028

Description	GN44028 is a hypoxia inducible factor (HIF)-1 inhibitor, with an IC50 of 14 nM. GN44028 inhibits hypoxia-induced HIF-1α transcriptional activity without suppressing HIF-1α mRNA expression, HIF-1α protein accumulation, or HIF-1α/HIF-1β heterodimerization[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> HIF/HIF Prolyl-Hydroxylase
Target	IC50: 14 nM (HIF-1)[1].
References	[1]. Minegishi H, et al. Discovery of Indenopyrazoles as a New Class of Hypoxia Inducible Factor (HIF)-1 Inhibitors. ACS Med Chem Lett. 2013 Jan 27;4(2):297-301.

Molecular Formula	C₁₈H₁₅N₃O₂
Molecular Weight	305.33

Hazard Codes	Xi