2305379-66-0

2305379-66-0 structure

Name: BRD7-IN-1 free base
Chemical Name: BRD7-IN-1 free base
CAS Number: 2305379-66-0
Molecular Formula: C₂₂H₂₆N₄O₃
Molecular Weight: 394.47
Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
Create Date: 2019-06-01 17:09:58
Modify Date: 2024-01-08 15:57:44
BRD7-IN-1 free base, a modified derivative of BI7273 (BRD7/9 inhibitor), binds to a VHL ligand via a linker to form a PROTAC VZ185 (VZ185 against BRD7/9 with DC50s of 4.5 and 1.8 nM, respectively)[1].

Name	BRD7-IN-1 free base

Description	BRD7-IN-1 free base, a modified derivative of BI7273 (BRD7/9 inhibitor), binds to a VHL ligand via a linker to form a PROTAC VZ185 (VZ185 against BRD7/9 with DC50s of 4.5 and 1.8 nM, respectively)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain
Target	BRD7, BRD9[1]
References	[1]. Zoppi V, et al. Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel-Lindau (VHL) Based Dual Degrader Probe of BRD9 and BRD7. J Med Chem. 2019 Jan 24;62(2):699-726.

Molecular Formula	C₂₂H₂₆N₄O₃
Molecular Weight	394.47

Hazard Codes	Xi