2173037-97-1

2173037-97-1 structure

Name: LY2794193
Chemical Name: LY2794193
CAS Number: 2173037-97-1
Molecular Formula: C₁₆H₁₈N₂O₆
Molecular Weight: 334.32
Catalog: Signaling Pathways GPCR/G Protein mGluR
Create Date: 2019-03-30 16:18:03
Modify Date: 2024-01-30 10:59:27
LY2794193 is a highly potent and selective mGlu3 receptor agonist (hmGlu3 Ki=0.927 nM，EC50=0.47 nM; hmGlu2 Ki=412 nM，EC50=47.5 nM)[1].

Name	LY2794193

Description	LY2794193 is a highly potent and selective mGlu3 receptor agonist (hmGlu3 Ki=0.927 nM，EC50=0.47 nM; hmGlu2 Ki=412 nM，EC50=47.5 nM)[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> mGluR Research Areas >> Neurological Disease
Target	mGluR3:0.47 nM (EC50) mGluR3:0.927 nM (Ki) mGluR2:47.5 (EC50) mGluR2:412 (Ki)
References	[1]. Monn JA, et al. Synthesis and Pharmacological Characterization of C4β-Amide-Substituted 2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1 S,2 S,4 S,5 R,6 S)-2-Amino-4-[(3-methoxybenzoyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2794193), a Highly Potent and Selective mGlu3 Receptor Agonist. J Med Chem. 2018 Mar 22;61(6):2303-2328.