342795-08-8

342795-08-8 structure

Name: Bragsin2
Chemical Name: Bragsin2
CAS Number: 342795-08-8
Molecular Formula: C₁₁H₆F₃NO₅
Molecular Weight: 289.16
Catalog: Research Areas Cancer
Create Date: 2019-03-31 08:55:34
Modify Date: 2024-01-11 16:13:03
Bragsin2 is a potent, selective and noncompetitive nucleotide exchange factor BRAG2 inhibitor, with an IC50 of 3 μM. Bragsin2 binds at the interface between the PH domain of BRAG2 and the lipid bilayer, leads BRAG2 unable to activate lipidated Arf GTPase. Bragsin2 affects breast cancer stem cells[1].

Name	Bragsin2

Description	Bragsin2 is a potent, selective and noncompetitive nucleotide exchange factor BRAG2 inhibitor, with an IC50 of 3 μM. Bragsin2 binds at the interface between the PH domain of BRAG2 and the lipid bilayer, leads BRAG2 unable to activate lipidated Arf GTPase. Bragsin2 affects breast cancer stem cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
Target	IC50: 3 μM (BRAG2)[1]
In Vitro	Bragsin2 (50 μM) inhibits Arf GTPase activation in HeLa cells[1]. Bragsin2 (50 μM) inhibits the growth of SUM149 and S68, with no effect on SUM159, which lacks adhesion molecules such as integrins and cadherins[1].
References	[1]. Nawrotek A, et al. PH-domain-binding inhibitors of nucleotide exchange factor BRAG2 disrupt Arf GTPase signaling. Nat Chem Biol. 2019 Feb 11. doi: 10.1038/s41589-019-0228-3.