Bragsin2
Modify Date: 2025-09-02 06:53:24
Bragsin2 structure
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Common Name | Bragsin2 | ||
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| CAS Number | 342795-08-8 | Molecular Weight | 289.16 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C11H6F3NO5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Bragsin2Bragsin2 is a potent, selective and noncompetitive nucleotide exchange factor BRAG2 inhibitor, with an IC50 of 3 μM. Bragsin2 binds at the interface between the PH domain of BRAG2 and the lipid bilayer, leads BRAG2 unable to activate lipidated Arf GTPase. Bragsin2 affects breast cancer stem cells[1]. |
| Name | Bragsin2 |
|---|
| Description | Bragsin2 is a potent, selective and noncompetitive nucleotide exchange factor BRAG2 inhibitor, with an IC50 of 3 μM. Bragsin2 binds at the interface between the PH domain of BRAG2 and the lipid bilayer, leads BRAG2 unable to activate lipidated Arf GTPase. Bragsin2 affects breast cancer stem cells[1]. |
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| Related Catalog | |
| Target |
IC50: 3 μM (BRAG2)[1] |
| In Vitro | Bragsin2 (50 μM) inhibits Arf GTPase activation in HeLa cells[1]. Bragsin2 (50 μM) inhibits the growth of SUM149 and S68, with no effect on SUM159, which lacks adhesion molecules such as integrins and cadherins[1]. |
| References |
| Molecular Formula | C11H6F3NO5 |
|---|---|
| Molecular Weight | 289.16 |
| InChIKey | WJUILHMXVGFAIS-UHFFFAOYSA-N |
| SMILES | COc1ccc2oc(C(F)(F)F)cc(=O)c2c1[N+](=O)[O-] |
| Storage condition | 2-8°C |