2237054-53-2
2237054-53-2 structure
- Name: Tubulin inhibitor 1
- Chemical Name: Tubulin inhibitor 1
- CAS Number: 2237054-53-2
- Molecular Formula: C21H24N2O4
- Molecular Weight: 368.43
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Microtubule/Tubulin
- Create Date: 2019-03-03 21:42:58
- Modify Date: 2024-01-08 18:49:01
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Tubulin inhibitor 1 is a tubulin inhibitor, occupying the colchicine binding site, inhibits tubulin polymerization. Tubulin inhibitor 1 shows potent anti-tumor activity, casues cellular mitotic arrest in the G2/M phase, and induces cellular apoptosis[1].
| Name | Tubulin inhibitor 1 |
|---|
| Description | Tubulin inhibitor 1 is a tubulin inhibitor, occupying the colchicine binding site, inhibits tubulin polymerization. Tubulin inhibitor 1 shows potent anti-tumor activity, casues cellular mitotic arrest in the G2/M phase, and induces cellular apoptosis[1]. |
|---|---|
| Related Catalog | |
| Target |
Tubulin[1] |
| In Vitro | Tubulin inhibitor 1 (Compound 7a3) is a tubulin inhibitor, occupying the colchicine binding site, inhibits tubulin polymerization[1]. Tubulin inhibitor 1 has potent anti-proliferative activity against SK-OV-3, MDA-MB-231, HeLa, A549, CT26 and MCF-7 cells, with IC50s of 16.7 ± 3.0, 31.4 ± 0.7, 32.8 ± 2.9, 67.0 ± 0.8, 58.0 ± 2.4 and 35.4 ± 5.6 nM, respectively[1]. Tubulin inhibitor 1 (40, 80, and 160 nM) markedly causes cellular mitotic arrest in the G2/M phase, induces apoptosis in SK-OV-3 cells[1]. |
| In Vivo | Tubulin inhibitor 1 (50 mg/kg, i.p.) is well tolerated, significantly reduces tumour growth in Balb/c nude mice bearing SK-OV-3 cells[1]. |
| References |
| Molecular Formula | C21H24N2O4 |
|---|---|
| Molecular Weight | 368.43 |