960113-85-3
960113-85-3 structure
- Name: BR351
- Chemical Name: BR351
- CAS Number: 960113-85-3
- Molecular Formula: C20H25FN2O5S
- Molecular Weight: 424.49
- Catalog: Signaling Pathways Metabolic Enzyme/Protease MMP
- Create Date: 2019-03-03 16:20:25
- Modify Date: 2024-02-04 15:29:13
-
BR351 is a brain penetrant MMP inhibitor with IC50s of 4, 2, 11, 50 nM for MMP2, MMP8, MMP9 and MMP13, respectively[1]. Potential tools for the molecular imaging of activated MMPs with PET[2].
| Name | BR351 |
|---|
| Description | BR351 is a brain penetrant MMP inhibitor with IC50s of 4, 2, 11, 50 nM for MMP2, MMP8, MMP9 and MMP13, respectively[1]. Potential tools for the molecular imaging of activated MMPs with PET[2]. |
|---|---|
| Related Catalog | |
| Target |
MMP-9:11 nM (IC50) MMP-2:4 nM (IC50) MMP-8:2 nM (IC50) MMP13:50 nM (IC50) |
| In Vivo | [18F]BR351 Is quickly metabolized in plasma with 20.28% ± 5.41% of intact tracer remaining at 15 minutes postinjection[2]. |
| References |
| Molecular Formula | C20H25FN2O5S |
|---|---|
| Molecular Weight | 424.49 |
| Hazard Codes | Xi |
|---|