1643125-32-9

1643125-32-9 structure

Name: SAFit1
Chemical Name: SAFit1
CAS Number: 1643125-32-9
Molecular Formula: C₄₂H₅₃NO₁₁
Molecular Weight: 747.87
Catalog: Research Areas Metabolic Disease
Create Date: 2019-02-20 18:21:10
Modify Date: 2024-01-19 04:03:04
SAFit1 is a FK506 binding protein 51 (FKBP51)-specific inhibitor with a Ki of 4±0.3 nM[1][2].

Name	SAFit1

Description	SAFit1 is a FK506 binding protein 51 (FKBP51)-specific inhibitor with a Ki of 4±0.3 nM[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease Research Areas >> Neurological Disease
Target	Ki: 4±0.3 nM (FKBP51), >50000 nM (FKBP52)[1]
In Vitro	SAFit1 (1-1000 nM) potently stimulates neurite outgrowth in two neuronal cell lines (N2a and SH-SY5Y) as well as in primary hippocampal neurons. SAFit1 is active over a wide concentration range[1].
References	[1]. Gaali S, et al. Selective inhibitors of the FK506-binding protein 51 by induced fit. Nat Chem Biol. 2015 Jan;11(1):33-7. [2]. Sidibeh CO, et al. FKBP5 expression in human adipose tissue: potential role in glucose and lipid metabolism, adipogenesis and type 2 diabetes. Endocrine. 2018 Oct;62(1):116-128.