1096702-14-5
1096702-14-5 structure
- Name: EC0489
- Chemical Name: EC0489
- CAS Number: 1096702-14-5
- Molecular Formula: C111H156N22O43S2
- Molecular Weight: 2550.68
- Catalog: Research Areas Cancer
- Create Date: 2019-02-16 12:53:58
- Modify Date: 2025-08-25 10:44:42
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EC0489, a conjugate of folic acid and desacetyl vinblastine hydrazide, is a high-affinity ligand for the folate receptor (FR). Refractory or metastatic Tumor[1]. Small molecule-drug conjugate (SMDC)[2].
| Name | EC0489 |
|---|
| Description | EC0489, a conjugate of folic acid and desacetyl vinblastine hydrazide, is a high-affinity ligand for the folate receptor (FR). Refractory or metastatic Tumor[1]. Small molecule-drug conjugate (SMDC)[2]. |
|---|---|
| Related Catalog | |
| Target |
Folate receptor[1] |
| In Vitro | The affinity of EC0489 toward the folate receptor (FR) is approximately half of that of folic acid (relative affinity 0.50)[1]. FR-positive KB cells are highly sensitive to EC0489 with an IC50 of 5 nM[1]. |
| In Vivo | EC0489 has a favorable toxicology profile in Rats. EC0489 (2, 3, and 4 μmol/kg) has antitumor activity against mice KB tumor models in a dose-dependent manner[1]. |
| References |
| Molecular Formula | C111H156N22O43S2 |
|---|---|
| Molecular Weight | 2550.68 |