EC0489
Modify Date: 2025-08-25 10:44:42
EC0489 structure
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Common Name | EC0489 | ||
|---|---|---|---|---|
| CAS Number | 1096702-14-5 | Molecular Weight | 2550.68 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C111H156N22O43S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of EC0489EC0489, a conjugate of folic acid and desacetyl vinblastine hydrazide, is a high-affinity ligand for the folate receptor (FR). Refractory or metastatic Tumor[1]. Small molecule-drug conjugate (SMDC)[2]. |
| Name | EC0489 |
|---|
| Description | EC0489, a conjugate of folic acid and desacetyl vinblastine hydrazide, is a high-affinity ligand for the folate receptor (FR). Refractory or metastatic Tumor[1]. Small molecule-drug conjugate (SMDC)[2]. |
|---|---|
| Related Catalog | |
| Target |
Folate receptor[1] |
| In Vitro | The affinity of EC0489 toward the folate receptor (FR) is approximately half of that of folic acid (relative affinity 0.50)[1]. FR-positive KB cells are highly sensitive to EC0489 with an IC50 of 5 nM[1]. |
| In Vivo | EC0489 has a favorable toxicology profile in Rats. EC0489 (2, 3, and 4 μmol/kg) has antitumor activity against mice KB tumor models in a dose-dependent manner[1]. |
| References |
| Molecular Formula | C111H156N22O43S2 |
|---|---|
| Molecular Weight | 2550.68 |
| InChIKey | PHCAWPRQWLBYTH-HCDHKMFTSA-N |
| SMILES | CCC1(O)CC2CN(CCc3c([nH]c4ccccc34)C(C(=O)OC)(c3cc4c(cc3OC)N(C)C3C(O)(C(=O)NNC(=O)OCCSSCC(NC(=O)C(CCC(=O)NCC(O)C(O)C(O)C(O)CO)NC(=O)C(CCC(=O)O)NC(=O)C(CCC(=O)NCC(O)C(O)C(O)C(O)CO)NC(=O)C(CCC(=O)O)NC(=O)C(CCC(=O)NCC(O)C(O)C(O)C(O)CO)NC(=O)CCC(NC(=O)c5ccc(NCc6c[nH]c7nc(N)nc(=O)c-7n6)cc5)C(=O)O)C(=O)O)C(O)C5(CC)C=CCN6CCC43C65)C2)C1 |