1242441-58-2
1242441-58-2 structure
- Name: 11C-MK-3168
- Chemical Name: 11C-MK-3168
- CAS Number: 1242441-58-2
- Molecular Formula: C2011CH21ClN4OS
- Molecular Weight: 411.94
- Catalog: Signaling Pathways Metabolic Enzyme/Protease FAAH
- Create Date: 2019-02-09 12:48:03
- Modify Date: 2024-01-09 14:53:52
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11C-MK-3168 is a potent, reversible and blood/brain barrier penetrated fatty acid amide hydrolase (FAAH) inhibitor, with IC50s of 1.0, 1.7 and 5.5 nM for human, rat and rhesus FAAH, respectively.
| Name | 11C-MK-3168 |
|---|
| Description | 11C-MK-3168 is a potent, reversible and blood/brain barrier penetrated fatty acid amide hydrolase (FAAH) inhibitor, with IC50s of 1.0, 1.7 and 5.5 nM for human, rat and rhesus FAAH, respectively. |
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| Related Catalog | |
| Target |
IC50: 1.0 nM (Human FAAH), 1.7 nM (Rat FAAH), 5.5 nM (Rhesus FAAH)[1] |
| In Vitro | 11C-MK-3168 is a potent and reversible fatty acid amide hydrolase (FAAH) inhibitor, with IC50s of 1.0, 1.7 and 5.5 nM for human, rat and rhesus FAAH, respectively. 11C-MK-3168 also shows selectivity over hERG (IC50 = 37 μM) and DLZ (IC50 = 16 μM); CYP 3A4 (IC50 > 50 μM); and the two cannabinoid receptors, CB1 (IC50 = 30 μM) and CB2 (IC50 = 150 μM)[1]. |
| References |
| Molecular Formula | C2011CH21ClN4OS |
|---|---|
| Molecular Weight | 411.94 |