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638213-98-6

638213-98-6 structure
638213-98-6 structure

Name AGL-2263
Synonyms (2E)-2-(3,4-Dihydroxybenzoyl)-3-(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)acrylonitrile
Benzenepropanenitrile, α-[(2,3-dihydro-2-oxo-5-benzoxazolyl)methylene]-3,4-dihydroxy-β-oxo-, (αE)-
Description AGL-2263 is an insulin receptor (IR) blocker.
Related Catalog
Target

Insulin receptor[1].

In Vitro AGL-2263 is an insulin receptor (IR) blocker[1].
Cell Assay Trophoblast cells are prepared from normal or GDM placentas. They are incubated in the presence of stimulants, insulin (100 nM) or both insulin and AGL-2263 (AGL, 5 μM) IR blocker, together for 24 hr[1].
References

[1]. Li Y, et al. GDM-associated insulin deficiency hinders the dissociation of SERT from ERp44 and down-regulates placental 5-HT uptake. Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):E5697-705.

Density 1.5±0.1 g/cm3
Molecular Formula C17H10N2O5
Molecular Weight 322.272
Exact Mass 322.058960
LogP 1.72
Index of Refraction 1.728
Storage condition 2-8℃
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