914088-09-8
914088-09-8 structure
- Name: Brentuximab
- Chemical Name: Brentuximab
- CAS Number: 914088-09-8
- Molecular Formula:
- Molecular Weight:
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2018-07-14 11:48:07
- Modify Date: 2024-01-11 20:28:32
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Brentuximab vedotin (cAC10-vcMMAE) is an antibody-drug conjugate (ADC) comprising an anti-CD30 antibody and the cytotoxic agent Monomethyl auristatin E (MMAE). Brentuximab vedotin inhibits CD30-positive cells with an IC50 of 2.5 ng/mL. Brentuximab vedotin can be used for the research of relapsed and refractory Hodgkin lymphoma[1][2].
| Name | Brentuximab |
|---|
| Description | Brentuximab vedotin (cAC10-vcMMAE) is an antibody-drug conjugate (ADC) comprising an anti-CD30 antibody and the cytotoxic agent Monomethyl auristatin E (MMAE). Brentuximab vedotin inhibits CD30-positive cells with an IC50 of 2.5 ng/mL. Brentuximab vedotin can be used for the research of relapsed and refractory Hodgkin lymphoma[1][2]. |
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| Related Catalog | |
| Target |
IC50: 2.5 ng/mL (CD30) |
| In Vitro | Brentuximab vedotin (cAC10-vcMMAE) (1 μg/mL; 96 h) has cytotoxicity to CD30+ in Karpas 299 cells[2]. .Brentuximab vedotin (CAC10-VCMMAE) (1 μg/mL; 12, 24 and 48 h) selectively induces growth arrest in G2/M phase then lead to apoptotic cell death[2]. . Cell Cytotoxicity Assay[2] Cell Line: Karpas 299 cells Concentration: 1 μg/mL Incubation Time: 96 h Result: Potently cytotoxic to CD30+ Karpas 299 cells, with an IC50 value of 2.5 ng/mL. Cell Cycle Analysis[2] Cell Line: L540 cells Concentration: 1 μg/mL Incubation Time: 12, 24, and 48 h Result: Selectively induced growth arrest in G2/M phase by apoptotic cell death. |
| In Vivo | Brentuximab vedotin (cAC10-vcMMAE) (10 to 120 mg/kg; intravenous injection; monitor for 3 weeks) to determine the maximum tolerated dose (MTD) is between 30 and 40 mg/kg[2]. Brentuximab vedotin (cAC10-vcMMAE) (0.3, 1 mg/kg; flanks injection; every 4 days for a total of 4 doses 1 mg/kg) can induce tumor CD30 regression[2]. Animal Model: SCID mice[2] Dosage: 10 to 120 mg/kg Administration: Intravenous injection; 10 to 120 mg/kg; for 3 weeks Result: Maximum tolerated dose (MTD) was between 30 and 40 mg/kg. Animal Model: SCID mice[2] Dosage: 0.3, 1 mg/kg Administration: Flanks injection; 1 mg/kg every 4 days for a total of 4 doses; 0.3 mg/kg every 4 days for a total of 4 doses Result: Induced complete, durable tumor regression, but 0.3 mg/kg provided lower therapy than 1 mg/kg dose. |
| References |
| No Any Chemical & Physical Properties |