1357266-05-7
1357266-05-7 structure
- Name: RO 5263397
- Chemical Name: RO5263397
- CAS Number: 1357266-05-7
- Molecular Formula: C10H11FN2O
- Molecular Weight: 194.2055432
- Catalog: Research Areas Neurological Disease
- Create Date: 2018-06-13 03:39:27
- Modify Date: 2024-01-09 16:54:38
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RO5263397 is a potent, selective, and orally available TAAR1 agonist, with EC50s of 17 and 35 nM for human TAAR1 and rat TAAR1, respectively. RO5263397 regulates wakefulness and EEG spectral composition. Antidepressant-like effect[1][2][3].
| Name | RO5263397 |
|---|
| Description | RO5263397 is a potent, selective, and orally available TAAR1 agonist, with EC50s of 17 and 35 nM for human TAAR1 and rat TAAR1, respectively. RO5263397 regulates wakefulness and EEG spectral composition. Antidepressant-like effect[1][2][3]. |
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| Related Catalog | |
| In Vivo | RO5263397 (0.1-1.0 mg/kg; p.o.; dosing at the mid-light phase (ZT6)) increased wake time at 0.3 and 1 mg/kg[2]. RO5263397 (0.3 and 1.0 mg/kg; p.o.) decreases NREM time in WT mice. RO5263397 (0.3 and 1.0 mg/kg; p.o.; in OE mice) powerfully increases W time in OE mice for 5-6 h. NREM sleep is suppressed for 4-6 h and REM sleep is almost completely suppressed for 6 h after all doses of RO5263397[3]. Animal Model: Adult 4-5-month-old male WT littermates (C57BL/6 background)[2] Dosage: 0.1, 0.3, 1 mg/kg Administration: p.o.; dosing at the mid-light phase (ZT6) Result: Increased wake time at 0.3 and 1 mg/kg |
| References |
| Molecular Formula | C10H11FN2O |
|---|---|
| Molecular Weight | 194.2055432 |