1316760-76-5

1316760-76-5 structure

Name: ETP-47037
Chemical Name: 5-(2-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinopyrazolo[1,5-a]pyrazin-6-yl)pyrimidin-2-amine
CAS Number: 1316760-76-5
Molecular Formula: C₂₀H₂₇N₉O₃S
Molecular Weight: 473.55188
Catalog: Signaling Pathways PI3K/Akt/mTOR PI3K
Create Date: 2018-06-10 14:05:32
Modify Date: 2024-01-29 14:49:26
ETP-47037 is a potent and inhibitor of PI3Kα isoform with an IC50 value of 0.99 nM. ETP-47037 also inhibits the PI3Kβ, PI3Kδ, and PI3Kγ isoforms, with IC50 values of 49.2, 7.13, and 49.1 nM, respectively. ETP-47037 has the potential for the research of chemical modulation of telomere protection[1].

Name	5-(2-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinopyrazolo[1,5-a]pyrazin-6-yl)pyrimidin-2-amine

Description	ETP-47037 is a potent and inhibitor of PI3Kα isoform with an IC50 value of 0.99 nM. ETP-47037 also inhibits the PI3Kβ, PI3Kδ, and PI3Kγ isoforms, with IC50 values of 49.2, 7.13, and 49.1 nM, respectively. ETP-47037 has the potential for the research of chemical modulation of telomere protection[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> PI3K/Akt/mTOR >> PI3K
References	[1]. Méndez-Pertuz M, et al. Modulation of telomere protection by the PI3K/AKT pathway. Nat Commun. 2017;8(1):1278.

Molecular Formula	C₂₀H₂₇N₉O₃S
Molecular Weight	473.55188