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92092-36-9

92092-36-9 structure
92092-36-9 structure
  • Name: Diphtheria toxin CRM197
  • Chemical Name: DIPHTHERIA TOXIN
  • CAS Number: 92092-36-9
  • Molecular Formula:
  • Molecular Weight:
  • Catalog: Research Areas Infection
  • Create Date: 2018-07-17 03:53:33
  • Modify Date: 2024-01-02 02:52:20
  • Diphtheria toxin CRM197, a nontoxic variant of diphtheria toxin, has a single mutation (Glycine to Glutamate substitution at position 52) that eliminates its toxicity. CRM197 is widely used as a carrier protein in conjugate vaccines[1].
Name DIPHTHERIA TOXIN
Description Diphtheria toxin CRM197, a nontoxic variant of diphtheria toxin, has a single mutation (Glycine to Glutamate substitution at position 52) that eliminates its toxicity. CRM197 is widely used as a carrier protein in conjugate vaccines[1].
Related Catalog
In Vitro Diphtheria toxin CRM197 is an enzymatically inactive and nontoxic form of diphtheria toxin that contains a single amino acid substitution (G52E). Being naturally nontoxic, CRM197 is an ideal carrier protein for conjugate vaccines against encapsulated bacteria and is currently used to vaccinate children globally against Haemophilus influenzae, pneumococcus, and meningococcus[1][2]. Diphtheria toxin, a single polypeptide secreted by lysogenic strains of Corynebacterium diphtheria, causes the disease diphtheria in humans by gaining entry into the cytoplasm of cells and inhibiting protein synthesis[3][4].
References

[1]. Ravi P N Mishra, et al. Structural and Immunological Characterization of E. coli Derived Recombinant CRM 197 Protein Used as Carrier in Conjugate Vaccines. Biosci Rep. 2018 Sep 25;38(5):BSR20180238.

[2]. Enrico Malito, et al. Structural Basis for Lack of Toxicity of the Diphtheria Toxin Mutant CRM197. Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5229-34.

[3]. C E Bell, et al. Crystal Structure of Diphtheria Toxin Bound to Nicotinamide Adenine Dinucleotide. Biochemistry. 1996 Jan 30;35(4):1137-49.

[4]. Ranjit Sah, et al. Diphtheria. N Engl J Med. 2019 Sep 26;381(13):1267.
Appearance lyophilized powder
Storage condition 2-8°C
Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H300
Precautionary Statements Missing Phrase - N15.00950417
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes T+
Risk Phrases 28
Safety Phrases 22-24/25-45-36/37-28
RIDADR 3172
WGK Germany 3
RTECS XW5807200
Packaging Group I
Hazard Class 6.1(a)

Chemsrc provides CAS#:92092-36-9 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 92092-36-9 | Chemsrc address: https://www.chemsrc.com/en/baike/1543147.html

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