79183-37-2
79183-37-2 structure
- Name: VU0119498
- Chemical Name: 1-(4-BROMOBENZYL)INDOLE-2,3-DIONE
- CAS Number: 79183-37-2
- Molecular Formula: C15H10BrNO2
- Molecular Weight: 316.153
- Catalog: Signaling Pathways GPCR/G Protein mAChR
- Create Date: 2018-06-17 01:50:21
- Modify Date: 2024-03-07 13:45:20
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VU0119498 is a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM), with EC50s of 6.04, 6.38, and 4.08 µM, respectively. VU0119498 has antidiabetic activity[1][2][3].
| Name | 1-(4-BROMOBENZYL)INDOLE-2,3-DIONE |
|---|---|
| Synonyms | VU0119498 |
| Description | VU0119498 is a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM), with EC50s of 6.04, 6.38, and 4.08 µM, respectively. VU0119498 has antidiabetic activity[1][2][3]. |
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| Related Catalog | |
| In Vitro | VU0119498 (0.01-30 μM; 150 s) potentiates Ach responses in M1, M3, and M5-expressing CHO cells, with EC50s of 6.04, 6.38, and 4.08 µM, respectively[1]. VU0119498 (3-20 μM) augments ACh-mediated increasing in insulin secretion and intracellular calcium levels in MIN6-K8 cells[3]. VU0119498 (20 μM; 90 min) enhances ACh-induced insulin release in mouse and human pancreatic islets[3]. |
| In Vivo | VU0119498 (0.1-2 mg/kg; a single i.p.) improves glucose tolerance and insulin secretion in mice in a β-cell M3R-dependent fashion[3]. VU0119498 (0.5 mg/kg; a single i.p.) improves glucose tolerance and insulin secretion in obese, glucose-intolerant mice[3]. Animal Model: Male WT mice (12 weeks)[3] Dosage: 0.1, 0.5, 2 mg/kg Administration: A single i.p. Result: Caused a significant improvement in glucose tolerance at the dose of 0.5 mg/kg. Significantly augmented GSIS at the dose of 0.5 mg/kg. |
| References |
| Molecular Formula | C15H10BrNO2 |
|---|---|
| Molecular Weight | 316.153 |
| Storage condition | -20°C |
| Hazard Codes | Xn |
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