172998-24-2
172998-24-2 structure
- Name: BUFORIN II
- Chemical Name: BUFORIN II
- CAS Number: 172998-24-2
- Molecular Formula: C106H184N40O26
- Molecular Weight: 2434.87
- Catalog: Signaling Pathways Anti-infection Bacterial
- Create Date: 2018-07-21 18:36:36
- Modify Date: 2024-01-10 17:11:18
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Buforin II, derived from buforin I, a protein isolated from the stomach of the Asian toad Bufo bufo gargarizans, is a potent antimicrobial peptide. Buforin II has antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria[1].
| Name | BUFORIN II |
|---|
| Description | Buforin II, derived from buforin I, a protein isolated from the stomach of the Asian toad Bufo bufo gargarizans, is a potent antimicrobial peptide. Buforin II has antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria[1]. |
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| Related Catalog | |
| In Vitro | Buforin II inhibits A. baumanniiATCC 19606 and multiresistant strains with the similar MIC values of 8 mg/L[1]. |
| In Vivo | Buforin II (intravenously a single dose, 1 mg/kg) has potent antibacterial activity that effectively reduces lethality and leads to a significant reduction in plasma endotoxin and cytokine concentrations in male Wistar rat model of sepsis[1]. Animal Model: Male Wistar rats weighing 200 to 300 g with A. baumannii ATCC 19606[1] Dosage: 1 mg/kg Administration: Intravenously a single dose Result: Reduced mortality by 40% in the treatment group and by 20% in the rifampicin (10 mg/kg) combination group. Reduced TNF, IL-6 and endotoxin plasma levels by 33%, 25% and 32%, respectively. Animal Model: Male Wistar rats weighing 200 to 300 g with the multiresistant strain[1] Dosage: 1 mg/kg Administration: Intravenously a single dose Result: Reduced mortality by 46.6% in the treatment group and by 20% in the rifampicin (10 mg/kg) combination group. Reduced TNF, IL-6 and endotoxin plasma levels by 46%, 20% and 28%, respectively. |
| References |
| Molecular Formula | C106H184N40O26 |
|---|---|
| Molecular Weight | 2434.87 |
| Storage condition | −20°C |