1061354-48-0
- Name: AVN-101 hydrochloride
- Chemical Name: AVN-101
- CAS Number: 1061354-48-0
- Molecular Formula: C21H25ClN2
- Molecular Weight: 340.9
- Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
- Create Date: 2018-07-13 23:40:38
- Modify Date: 2026-07-06 10:38:34
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AVN-101 hydrochloride is a potent, brain-penetrant and orally active 5-HT7 receptor antagonist (Ki of 153 pM), with slightly lesser potency toward 5-HT6, 5-HT2A, and 5HT-2C receptors (Ki values of 2.04 nM, 1.56 nM, and 1.17 nM, respectively). AVN-101 hydrochloride also exhibits a rather high affinity toward histamine H1 (Ki of 0.58 nM) and adrenergic α2A, α2B, and α2C (Ki= 0.41-3.6 nM) receptors. AVN-101 hydrochloride can be studied in such diseases as general anxiety disorders, depression, schizophrenia, and multiple sclerosis[1].
| Name | AVN-101 |
|---|
| Description | AVN-101 hydrochloride is a potent, brain-penetrant and orally active 5-HT7 receptor antagonist (Ki of 153 pM), with slightly lesser potency toward 5-HT6, 5-HT2A, and 5HT-2C receptors (Ki values of 2.04 nM, 1.56 nM, and 1.17 nM, respectively). AVN-101 hydrochloride also exhibits a rather high affinity toward histamine H1 (Ki of 0.58 nM) and adrenergic α2A, α2B, and α2C (Ki= 0.41-3.6 nM) receptors. AVN-101 hydrochloride can be studied in such diseases as general anxiety disorders, depression, schizophrenia, and multiple sclerosis[1]. |
|---|---|
| Related Catalog | |
| Target |
5-HT7 Receptor:0.153 nM (Ki) 5-HT2C Receptor:1.17 nM (Ki) 5-HT2A Receptor:1.56 nM (Ki) 5-HT6 Receptor:2.04 nM (Ki) 5-HT2B Receptor:10.6 nM (Ki) 5-HT1A Receptor:61 nM (Ki) 5-HT1B Receptor:720 nM (Ki) H1 Receptor:0.58 nM (Ki) Alpha-2B adrenergic receptor:0.41 nM (Ki) Alpha-2A adrenergic receptor:1.77 nM (Ki) Alpha-2C adrenergic receptor:3.55 nM (Ki) Alpha-1B adrenergic receptor:9.4 nM (Ki) Alpha-1A adrenergic receptor:18.9 nM (Ki) Alpha-1D adrenergic receptor:30.2 nM (Ki) |
| References |
| Molecular Formula | C21H25ClN2 |
|---|---|
| Molecular Weight | 340.9 |
| Exact Mass | 340.1706265 |