1649450-12-3

1649450-12-3 structure

Name: ML352
Chemical Name: N-[(3-Isopropyl-1,2-oxazol-5-yl)methyl]-4-methoxy-3-[(1-methyl-4-piperidinyl)oxy]benzamide
CAS Number: 1649450-12-3
Molecular Formula: C₂₁H₂₉N₃O₄
Molecular Weight: 387.473
Create Date: 2018-07-05 19:54:52
Modify Date: 2025-08-25 07:32:32
ML352 is a noncompetitive inhibitor of the presynaptic choline transporter (CHT) with Kivalues of 92 and 166 nM for HEK293 cells expressing human CHT and mouse forebrain synaptosomes, respectively[1].

Name	N-[(3-Isopropyl-1,2-oxazol-5-yl)methyl]-4-methoxy-3-[(1-methyl-4-piperidinyl)oxy]benzamide
Synonyms	N-[(3-Isopropyl-1,2-oxazol-5-yl)methyl]-4-methoxy-3-[(1-methyl-4-piperidinyl)oxy]benzamide MFCD28975158 Benzamide, 4-methoxy-N-[[3-(1-methylethyl)-5-isoxazolyl]methyl]-3-[(1-methyl-4-piperidinyl)oxy]-

Description	ML352 is a noncompetitive inhibitor of the presynaptic choline transporter (CHT) with Kivalues of 92 and 166 nM for HEK293 cells expressing human CHT and mouse forebrain synaptosomes, respectively[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> AChE
References	[1]. Ennis EA, Wright J, Retzlaff CL, McManus OB, Lin Z, Huang X, et al. Identification and characterization of ML352: a novel, noncompetitive inhibitor of the presynaptic choline transporter. ACS Chem Neurosci. 2015 Mar 18;6(3):417-27.