937263-81-5

937263-81-5 structure

Name: ONT-993
Chemical Name: {4-Methyl-2-[(4-{[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]amino}-6-quinazolinyl)amino]-4,5-dihydro-1,3-oxazol-4-yl}methanol
CAS Number: 937263-81-5
Molecular Formula: C₂₆H₂₄N₈O₃
Molecular Weight: 496.52
Catalog: Signaling Pathways Metabolic Enzyme/Protease Cytochrome P450
Create Date: 2018-06-09 04:59:09
Modify Date: 2024-01-03 11:00:03
ONT-993 is an aliphatic hydroxylated metabolite. ONT-993 inhibits CYP2D6 (IC50=7.9 µM) and causes metabolism-dependent inactivation of CYP3A (KI=1.6 µM)[1].

Name	{4-Methyl-2-[(4-{[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]amino}-6-quinazolinyl)amino]-4,5-dihydro-1,3-oxazol-4-yl}methanol
Synonyms	{4-Methyl-2-[(4-{[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]amino}-6-quinazolinyl)amino]-4,5-dihydro-1,3-oxazol-4-yl}methanol 4-Oxazolemethanol, 4,5-dihydro-4-methyl-2-[[4-[[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]amino]-6-quinazolinyl]amino]-

Description	ONT-993 is an aliphatic hydroxylated metabolite. ONT-993 inhibits CYP2D6 (IC50=7.9 µM) and causes metabolism-dependent inactivation of CYP3A (KI=1.6 µM)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450
Target	CYP2D6:7.9 μM (IC50)
References	[1]. Sun H, et al. Elimination of tucatinib, a small molecule kinase inhibitor of HER2, is primarily governed by CYP2C8 enantioselective oxidation of gem-dimethyl. Cancer Chemother Pharmacol. 2022 Jun;89(6):737-750.