ONT-993

Modify Date: 2024-01-03 11:00:03

ONT-993 structure	Common Name	ONT-993
	CAS Number	937263-81-5	Molecular Weight	496.52
	Density	1.5±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₂₆H₂₄N₈O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of ONT-993

ONT-993 is an aliphatic hydroxylated metabolite. ONT-993 inhibits CYP2D6 (IC50=7.9 µM) and causes metabolism-dependent inactivation of CYP3A (KI=1.6 µM)[1].

Name	{4-Methyl-2-[(4-{[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]amino}-6-quinazolinyl)amino]-4,5-dihydro-1,3-oxazol-4-yl}methanol
Synonym	More Synonyms

Description	ONT-993 is an aliphatic hydroxylated metabolite. ONT-993 inhibits CYP2D6 (IC50=7.9 µM) and causes metabolism-dependent inactivation of CYP3A (KI=1.6 µM)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450
Target	CYP2D6:7.9 μM (IC50)
References	[1]. Sun H, et al. Elimination of tucatinib, a small molecule kinase inhibitor of HER2, is primarily governed by CYP2C8 enantioselective oxidation of gem-dimethyl. Cancer Chemother Pharmacol. 2022 Jun;89(6):737-750.

Density	1.5±0.1 g/cm3
Molecular Formula	C₂₆H₂₄N₈O₃
Molecular Weight	496.52
Exact Mass	496.197144
LogP	2.38
Index of Refraction	1.742

{4-Methyl-2-[(4-{[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]amino}-6-quinazolinyl)amino]-4,5-dihydro-1,3-oxazol-4-yl}methanol

4-Oxazolemethanol, 4,5-dihydro-4-methyl-2-[[4-[[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]amino]-6-quinazolinyl]amino]-

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ONT-993

Use of ONT-993

Names

ONT-993 Biological Activity

Chemical & Physical Properties

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.