Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 7α,15-Dihydroxydehydroabieticacid
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Purity: 98.0%
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155205-64-4

155205-64-4 structure

155205-64-4 structure

Name: 7α,15-Dihydroxydehydroabietic acid
Chemical Name: (7α)-7,15-Dihydroxyabieta-8,11,13-trien-18-oic acid
CAS Number: 155205-64-4
Molecular Formula: C₂₀H₂₈O₄
Molecular Weight: 332.434
Catalog: Natural product Moss
Create Date: 2018-07-03 10:28:39
Modify Date: 2025-08-25 14:51:33
7α,15-Dihydroxydehydroabietic acid is a natural abietane-type diterpenoid with antiangiogenic effects[1].

Name	(7α)-7,15-Dihydroxyabieta-8,11,13-trien-18-oic acid
Synonyms	(7α)-7,15-Dihydroxyabieta-8,11,13-trien-18-oic acid 1-Phenanthrenecarboxylic acid, 1,2,3,4,4a,9,10,10a-octahydro-9-hydroxy-7-(1-hydroxy-1-methylethyl)-1,4a-dimethyl-, (1R,4aS,9R,10aR)-

Description	7α,15-Dihydroxydehydroabietic acid is a natural abietane-type diterpenoid with antiangiogenic effects[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> MAPK/ERK Pathway >> ERK Signaling Pathways >> Stem Cell/Wnt >> ERK
In Vitro	7α,15-Dihydroxydehydroabietic acid（3.125-100 μM；24 小时）显着降低 HUVEC 细胞活力[1]。 7α,15-Dihydroxydehydroabietic acid (3.125-6.25 μM; 24 小时) 显着抑制 HUVEC 中血管生成的促进作用。7α,15-Dihydroxydehydroabietic acid 通过下调 VEGF、p-Akt 和 p-ERK 信号通路抑制血管生成[1]。 Cell Viability Assay[1] Cell Line: Human umbilical vein endothelial cells (HUVECs) Concentration: 3.125 μM, 6.25 μM, 12.5 μM, 25 μM, 50 μM, 100 μM Incubation Time: 24 hours Result: Significantly decreased HUVEC cell viability. Western Blot Analysis[1] Cell Line: Human umbilical vein endothelial cells (HUVECs) Concentration: 3.125 μM, 6.25 μM Incubation Time: 24 hours Result: Human umbilical vein endothelial cells (HUVECs)[1]3.125 μM, 6.25 μM24 hoursShowed downregulation of VEGF, p-Akt and p-ERK in HUVECs.
References	[1]. Tae Kyoung Lee, et al. 7α,15-Dihydroxydehydroabietic acid from Pinus koraiensis inhibits the promotion of angiogenesis through downregulation of VEGF, p-Akt and p-ERK in HUVECs. Bioorg Med Chem Lett. 2018 Apr 1;28(6):1084-1089.

Density	1.2±0.1 g/cm3
Boiling Point	511.4±50.0 °C at 760 mmHg
Molecular Formula	C₂₀H₂₈O₄
Molecular Weight	332.434
Flash Point	277.2±26.6 °C
Exact Mass	332.198761
LogP	2.84
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.573

Hazard Codes	Xi

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