155205-64-4
155205-64-4 structure
- Name: 7α,15-Dihydroxydehydroabietic acid
- Chemical Name: (7α)-7,15-Dihydroxyabieta-8,11,13-trien-18-oic acid
- CAS Number: 155205-64-4
- Molecular Formula: C20H28O4
- Molecular Weight: 332.434
- Catalog: Natural product Moss
- Create Date: 2018-07-03 10:28:39
- Modify Date: 2024-01-20 06:10:13
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7α,15-Dihydroxydehydroabietic acid is a natural abietane-type diterpenoid with antiangiogenic effects[1].
| Name | (7α)-7,15-Dihydroxyabieta-8,11,13-trien-18-oic acid |
|---|---|
| Synonyms |
(7α)-7,15-Dihydroxyabieta-8,11,13-trien-18-oic acid
1-Phenanthrenecarboxylic acid, 1,2,3,4,4a,9,10,10a-octahydro-9-hydroxy-7-(1-hydroxy-1-methylethyl)-1,4a-dimethyl-, (1R,4aS,9R,10aR)- |
| Description | 7α,15-Dihydroxydehydroabietic acid is a natural abietane-type diterpenoid with antiangiogenic effects[1]. |
|---|---|
| Related Catalog | |
| In Vitro | 7α,15-Dihydroxydehydroabietic acid（3.125-100 μM；24 小时）显着降低 HUVEC 细胞活力[1]。 7α,15-Dihydroxydehydroabietic acid (3.125-6.25 μM; 24 小时) 显着抑制 HUVEC 中血管生成的促进作用。7α,15-Dihydroxydehydroabietic acid 通过下调 VEGF、p-Akt 和 p-ERK 信号通路抑制血管生成[1]。 Cell Viability Assay[1] Cell Line: Human umbilical vein endothelial cells (HUVECs) Concentration: 3.125 μM, 6.25 μM, 12.5 μM, 25 μM, 50 μM, 100 μM Incubation Time: 24 hours Result: Significantly decreased HUVEC cell viability. Western Blot Analysis[1] Cell Line: Human umbilical vein endothelial cells (HUVECs) Concentration: 3.125 μM, 6.25 μM Incubation Time: 24 hours Result: Human umbilical vein endothelial cells (HUVECs)[1]3.125 μM, 6.25 μM24 hoursShowed downregulation of VEGF, p-Akt and p-ERK in HUVECs. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 511.4±50.0 °C at 760 mmHg |
| Molecular Formula | C20H28O4 |
| Molecular Weight | 332.434 |
| Flash Point | 277.2±26.6 °C |
| Exact Mass | 332.198761 |
| LogP | 2.84 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.573 |
| Hazard Codes | Xi |
|---|