1143579-78-5

1143579-78-5 structure

Name: II-B08
Chemical Name: 3-{1-[3-(4-Biphenylylamino)-3-oxopropyl]-1H-1,2,3-triazol-4-yl}-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid
CAS Number: 1143579-78-5
Molecular Formula: C₃₃H₂₇N₅O₄
Molecular Weight: 557.599
Catalog: Research Areas Cancer
Create Date: 2018-07-14 05:09:17
Modify Date: 2025-11-25 11:29:34
II-B08 is a reversible and noncompetitive SHP2 inhibitor (IC50: 5.5 μM, 15.7, 14.3 μM for SHP2, SHP1, PTP1B). II-B08 can be used for cancer research[1].

Name	3-{1-[3-(4-Biphenylylamino)-3-oxopropyl]-1H-1,2,3-triazol-4-yl}-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid
Synonyms	3-{1-[3-(4-Biphenylylamino)-3-oxopropyl]-1H-1,2,3-triazol-4-yl}-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid 3-{1-[3-(biphenyl-4-ylamino)-3-oxopropyl]-1H-1,2,3-triazol-4-yl}-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid 1H-Indole-5-carboxylic acid, 3-[1-[3-([1,1'-biphenyl]-4-ylamino)-3-oxopropyl]-1H-1,2,3-triazol-4-yl]-6-hydroxy-1-methyl-2-phenyl-

Description	II-B08 is a reversible and noncompetitive SHP2 inhibitor (IC50: 5.5 μM, 15.7, 14.3 μM for SHP2, SHP1, PTP1B). II-B08 can be used for cancer research[1].
Related Catalog	Research Areas >> Cancer
References	[1]. Zeng LF, et al. Therapeutic potential of targeting the oncogenic SHP2 phosphatase. J Med Chem. 2014 Aug 14;57(15):6594-609. [2]. Zhang X, et al. Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2). J Med Chem. 2010 Mar 25;53(6):2482-93.