862901-87-9
862901-87-9 structure
- Name: LT175
- Chemical Name: (2S)-2-(4-Biphenylyloxy)-3-phenylpropanoic acid
- CAS Number: 862901-87-9
- Molecular Formula: C21H18O3
- Molecular Weight: 318.366
- Create Date: 2018-06-16 00:30:15
- Modify Date: 2024-04-02 22:02:48
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LT175, a dual PPARα/γ ligand, is an orally active partial agonist against PPARγ(hPPARα:EC50=0.22 μm; mPPARα:EC50=0.26 μm; hPPARγ:EC50=0.48 μm). LT175 interacts with PPARγ and affects the recruitment of the coregulators cyclic-AMP response element-binding protein-binding protein and nuclear corepressor 1 (NCoR1). LT175 interacts with PPARγ in a hydrophobic region called “diphenyl pocket”. LT175 has potent insulin-sensitizing effects and reduced adipogenic properties[1].
| Name | (2S)-2-(4-Biphenylyloxy)-3-phenylpropanoic acid |
|---|---|
| Synonyms |
Benzenepropanoic acid, α-([1,1'-biphenyl]-4-yloxy)-, (αS)-
(2S)-2-(4-Biphenylyloxy)-3-phenylpropanoic acid MFCD28386029 (2S)-2-(biphenyl-4-yloxy)-3-phenylpropanoic acid |
| Description | LT175, a dual PPARα/γ ligand, is an orally active partial agonist against PPARγ(hPPARα:EC50=0.22 μm; mPPARα:EC50=0.26 μm; hPPARγ:EC50=0.48 μm). LT175 interacts with PPARγ and affects the recruitment of the coregulators cyclic-AMP response element-binding protein-binding protein and nuclear corepressor 1 (NCoR1). LT175 interacts with PPARγ in a hydrophobic region called “diphenyl pocket”. LT175 has potent insulin-sensitizing effects and reduced adipogenic properties[1]. |
|---|---|
| Related Catalog | |
| Target |
hPPARα:0.22 μM (EC50) mPPARα:0.26 μM (EC50) hPPARγ:0.48 μM (EC50) |
| In Vivo | LT175 (100 mg/kg/day; orally; for 3 days) induces a significant decrease in body weight (11%) and reduces fasting blood glucose, triglycerides, and free fatty acids. LT175 decreases total plasma cholesterol significantly in diet-induced Insulin-resistant mice (six-week-old C57Bl/6J male mice)[1]. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 509.8±45.0 °C at 760 mmHg |
| Molecular Formula | C21H18O3 |
| Molecular Weight | 318.366 |
| Flash Point | 182.3±22.2 °C |
| Exact Mass | 318.125580 |
| LogP | 4.90 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.611 |
| Symbol |
GHS06, GHS09 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301-H410 |
| Precautionary Statements | P273-P301 + P310 + P330-P391-P501 |
| RIDADR | UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s., HI: all |