1421866-48-9

1421866-48-9 structure

Name	apimostinel
Synonyms	NRX-1074 L-Threonyl-L-prolyl-2-benzyl-L-prolyl-L-threoninamide apimostinel UNII:TTT1F11FZB TTT1F11FZB L-Threoninamide, L-threonyl-L-prolyl-2-(phenylmethyl)-L-prolyl-

Description	Apimostinel is an oral NMDA receptor partial agonist.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease
In Vitro	Apimostinel (NRX-1074) modulates the NMDA receptor in a similar fashion to GLYX-13, but has a synthetic modification to one of the amino acids, conferring increased potency and oral bioavailability[1].
In Vivo	In preclinical models the two compounds both appear to be highly efficacious across a number of CNS disorders[1].
References	[1]. Naurex's First Orally Active Molecule, NRX-1074, Demonstrates Statistically Significant Improvement in Depression Scores within 24 Hours in Phase 2 Study for Major Depressive Disorder. January 28, 2015.