213007-95-5

213007-95-5 structure

Name: Org 37684
Chemical Name: (S)-3-((5-methoxy-2,3-dihydro-1H-inden-4-yl)oxy)pyrrolidine hydrochloride
CAS Number: 213007-95-5
Molecular Formula: C₁₄H₂₀ClNO₂
Molecular Weight: 269.767
Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
Create Date: 2018-07-21 23:40:18
Modify Date: 2024-01-10 18:44:12
Org37684 is a highly potent 5-HT2C receptor agonist (pEC50=8.17). Org37684 exhibits a rank order of potency of 5-HT2C>5-HT2B>5-HT2A. Its selectivity for the 5-HT2C receptor is approximately 2.5 times over the 5-HT2B (pEC50=7.96) and ten times for the 5-HT2A (pEC50=7.11) receptor[1].

Name	(S)-3-((5-methoxy-2,3-dihydro-1H-inden-4-yl)oxy)pyrrolidine hydrochloride
Synonyms	Pyrrolidine, 3-[(2,3-dihydro-5-methoxy-1H-inden-4-yl)oxy]-, (3S)-, hydrochloride (1:1) (S)-3-((5-methoxy-2,3-dihydro-1H-inden-4-yl)oxy)pyrrolidine hydrochloride (3S)-3-[(5-Methoxy-2,3-dihydro-1H-inden-4-yl)oxy]pyrrolidine hydrochloride (1:1)

Description	Org37684 is a highly potent 5-HT2C receptor agonist (pEC50=8.17). Org37684 exhibits a rank order of potency of 5-HT2C>5-HT2B>5-HT2A. Its selectivity for the 5-HT2C receptor is approximately 2.5 times over the 5-HT2B (pEC50=7.96) and ten times for the 5-HT2A (pEC50=7.11) receptor[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
In Vitro	Org37684 is an agonist at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells[1].
References	[1]. Porter RH, et al. Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells. Br J Pharmacol. 1999;128(1):13-20.