1607828-35-2
1607828-35-2 structure
- Name: 2,3-Dihydro-3α-methoxynimbolide
- Chemical Name: Methyl [(2aS,3R,5aR,6S,6aR,8R,9aR,10aS,10bR,10cR)-8-(3-furyl)-3-methoxy-2a,5a,6a,7-tetramethyl-2,5-dioxo-2a,4,5,5a,6,6a,8,9,9a,10a,10b,10c-dodecahydro-2H,3H-cyclopenta[b]furo[2',3',4':4,5]naphtho[2,3-d]furan-6-yl]acetate
- CAS Number: 1607828-35-2
- Molecular Formula: C28H34O8
- Molecular Weight: 498.56
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2018-06-04 15:38:09
- Modify Date: 2025-08-25 11:55:15
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2,3-Dihydro-3α-methoxynimbolide is a limonoid compound isolated from the extracts of bark, leaves, roots, and seeds of Azadirachta indica A. Juss. var. siamensis Valeton. 2,3-Dihydro-3α-methoxynimbolide exhibits potent cyto-toxicities against one or more cell lines. 2,3-Dihydro-3α-methoxynimbolide activates caspases-3, -8, and -9, while increases the ratio of Bax/Bcl-2. 2,3-Dihydro-3α-methoxynimbolide induces apoptosis via both mitochondrial and death receptor pathways in AZ521[1].
| Name | Methyl [(2aS,3R,5aR,6S,6aR,8R,9aR,10aS,10bR,10cR)-8-(3-furyl)-3-methoxy-2a,5a,6a,7-tetramethyl-2,5-dioxo-2a,4,5,5a,6,6a,8,9,9a,10a,10b,10c-dodecahydro-2H,3H-cyclopenta[b]furo[2',3',4':4,5]naphtho[2,3-d]furan-6-yl]acetate |
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| Synonyms |
2H,3H-Cyclopenta[d]naphtho[2,3-b:1,8-b'c']difuran-6-acetic acid, 8-(3-furanyl)-2a,4,5,5a,6,6a,8,9,9a,10a,10b,10c-dodecahydro-3-methoxy-2a,5a,6a,7-tetramethyl-2,5-dioxo-, methyl ester, (2aS,3R,5aR,6S,6aR,8R,9aR,10aS,10bR,10cR)-
Methyl [(2aS,3R,5aR,6S,6aR,8R,9aR,10aS,10bR,10cR)-8-(3-furyl)-3-methoxy-2a,5a,6a,7-tetramethyl-2,5-dioxo-2a,4,5,5a,6,6a,8,9,9a,10a,10b,10c-dodecahydro-2H,3H-cyclopenta[b]furo[2',3',4':4,5]naphtho[2,3-d]furan-6-yl]acetate |
| Description | 2,3-Dihydro-3α-methoxynimbolide is a limonoid compound isolated from the extracts of bark, leaves, roots, and seeds of Azadirachta indica A. Juss. var. siamensis Valeton. 2,3-Dihydro-3α-methoxynimbolide exhibits potent cyto-toxicities against one or more cell lines. 2,3-Dihydro-3α-methoxynimbolide activates caspases-3, -8, and -9, while increases the ratio of Bax/Bcl-2. 2,3-Dihydro-3α-methoxynimbolide induces apoptosis via both mitochondrial and death receptor pathways in AZ521[1]. |
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| Related Catalog | |
| References |
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 617.7±55.0 °C at 760 mmHg |
| Molecular Formula | C28H34O8 |
| Molecular Weight | 498.56 |
| Flash Point | 327.3±31.5 °C |
| Exact Mass | 498.225372 |
| LogP | 2.28 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.577 |
| Storage condition | 2-8℃ |
| Hazard Codes | Xi |
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