1253291-12-1
1253291-12-1 structure
- Name: GRN-529
- Chemical Name: GRN-529
- CAS Number: 1253291-12-1
- Molecular Formula: C22H15F2N3O2
- Molecular Weight: 391.370
- Create Date: 2018-06-09 14:54:49
- Modify Date: 2023-09-07 17:19:51
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A highly potent, selective, orally active mGluR5 negative allosteric modulator with Ki of 5.4 nM, IC50 of 3.1 nM.
| Name | GRN-529 |
|---|---|
| Synonyms |
[4-(Difluoromethoxy)-3-(2-pyridinylethynyl)phenyl](5,7-dihydro-6H-pyrrolo[3,4-b]pyridin-6-yl)methanone
Methanone, [4-(difluoromethoxy)-3-[2-(2-pyridinyl)ethynyl]phenyl](5,7-dihydro-6H-pyrrolo[3,4-b]pyridin-6-yl)- (4-(difluoromethoxy)-3-(pyridin-2-ylethynyl)phenyl)(5H-pyrrolo[3,4-b]pyridin-6(7H)-yl)methanone GRN-529 |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 620.9±55.0 °C at 760 mmHg |
| Molecular Formula | C22H15F2N3O2 |
| Molecular Weight | 391.370 |
| Flash Point | 329.3±31.5 °C |
| Exact Mass | 391.113220 |
| LogP | 2.11 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.655 |
| RIDADR | NONH for all modes of transport |
|---|