119152-50-0

119152-50-0 structure

Name: Glychionide A
Chemical Name: 58792ZUT0H
CAS Number: 119152-50-0
Molecular Formula: C₂₁H₁₈O₁₁
Molecular Weight: 446.361
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2018-06-18 05:34:28
Modify Date: 2024-01-02 16:53:11
Glychionide A is a flavonoside that can be found in the roots of Glychirriza glabra. Glychionide A promotes apoptosis and autophagy of PANC-1 pancreatic cancer cells. Glychionide A can be used for the research of cancer[1][2].

Name	58792ZUT0H
Synonyms	GLYCHIONIDE A 5,8-Dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl β-D-glucopyranosiduronic acid 58792ZUT0H 4H-1-Benzopyran-4-one, 7-(β-D-glucopyranuronosyloxy)-5,8-dihydroxy-2-phenyl-

Description	Glychionide A is a flavonoside that can be found in the roots of Glychirriza glabra. Glychionide A promotes apoptosis and autophagy of PANC-1 pancreatic cancer cells. Glychionide A can be used for the research of cancer[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Autophagy >> Autophagy
In Vitro	Glychionide A (3.12-100 μM) significantly inhibits the proliferation of the PANC-1 pancreatic cancer cells, with an IC50 of 14 μM[1]. Glychionide A (7-28 μM) induces both autophagy and apoptosis in pancreatic cancer cells[1]. Glychionide A (7-28 μM) causes G2/M arrest of PANC-1 pancreatic cancer cells[1]. Glychionide A (7-28 μM) causes generation of ROS in PANC-1 cells[1].
References	[1]. Li JR, et, al. Two new compounds from Glycyrrhiza glabra. J Asian Nat Prod Res. 2005 Aug;7(4):677-80. [2]. Yu L, et, al. Antitumor Effects of Glychionide-A Flavonoid in Human Pancreatic Carcinoma Cells Are Mediated by Activation of Apoptotic and Autophagic Pathways, Cell Cycle Arrest, and Disruption of Mitochondrial Membrane Potential. Med Sci Monit. 2019 Feb 3;25:962-969.

Hazard Codes	Xi