774589-47-8

774589-47-8 structure

Name: ML406
Chemical Name: 1-{4-[4-(1,3-Benzodioxol-5-ylcarbonyl)-1-piperazinyl]phenyl}ethanone
CAS Number: 774589-47-8
Molecular Formula: C₂₀H₂₀N₂O₄
Molecular Weight: 352.384
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2018-07-12 23:00:18
Modify Date: 2024-01-13 15:25:07
ML406 is a small molecule probe that shows anti-tubercular activity via MtbbioA (DAPA synthase) enzyme inhibition with an IC50 of 30 nM[1].

Name	1-{4-[4-(1,3-Benzodioxol-5-ylcarbonyl)-1-piperazinyl]phenyl}ethanone
Synonyms	Ethanone, 1-[4-[4-(1,3-benzodioxol-5-ylcarbonyl)-1-piperazinyl]phenyl]- 1-{4-[4-(1,3-Benzodioxol-5-ylcarbonyl)-1-piperazinyl]phenyl}ethanone 1-{4-[4-(1,3-benzodioxol-5-ylcarbonyl)piperazin-1-yl]phenyl}ethanone MFCD06004413

Description	ML406 is a small molecule probe that shows anti-tubercular activity via MtbbioA (DAPA synthase) enzyme inhibition with an IC50 of 30 nM[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
Target	IC50 30 nM (BioA)[1]
In Vitro	ML406 inhibits WT Mycobacterium tuberculosis (Mtb) (H37Rv) growth inhibition with the IC50 of 3.2 μM. BioA is an enzyme involved in biotin biosynthesis in Mtb that may serve as lead compounds for drug development for tuberculosis (TB)[1].
References	[1]. Dominick Casalena, et al. Discovery of small molecule probe that shows anti-tubercular activity via MtbbioA (DAPA synthase) enzyme inhibition. January 16, 2015.