BioBioPha
China
Product Name: 8-Epixanthatin
Price: ￥4000.0/5mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Xueping-Zheng

30890-35-8

30890-35-8 structure

30890-35-8 structure

Name: 8-Epixanthatin
Chemical Name: 8DFW6D5G55
CAS Number: 30890-35-8
Molecular Formula: C₁₅H₁₈O₃
Molecular Weight: 246.302
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2018-07-09 12:19:28
Modify Date: 2024-01-09 14:14:00
8-Epixanthatin is a potential colchicine binding site inhibitor isolated from Xanthium chinese Mill. 8-Epixanthatin can inhibit the activation of STAT3, induce apoptosis, and has anti-tumor activity[1].

Name	8DFW6D5G55
Synonyms	8DFW6D5G55 8-epi-Xanthatin 2H-Cyclohepta[b]furan-2-one, 3,3a,4,7,8,8a-hexahydro-7-methyl-3-methylene-6-[(1E)-3-oxo-1-buten-1-yl]-, (3aR,7S,8aR)- (3aR,7S,8aR)-7-Methyl-3-methylene-6-[(1E)-3-oxo-1-buten-1-yl]-3,3a,4,7,8,8a-hexahydro-2H-cyclohepta[b]furan-2-one

Description	8-Epixanthatin is a potential colchicine binding site inhibitor isolated from Xanthium chinese Mill. 8-Epixanthatin can inhibit the activation of STAT3, induce apoptosis, and has anti-tumor activity[1].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> STAT Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> STAT
In Vitro	8-Epixanthatin(2-20 μM, 12 h) 可以以剂量依赖性方式抑制 DU145 细胞增殖和 DU145 细胞的 p-STAT3 水平，其 IC50 值为 3.2 μM[1]。 8-Epixanthatin可以通过诱导 DU145 癌细胞中 ROS 的产生抑制 STAT3 的激活和细胞增殖[1]。 Cell Proliferation Assay[1] Cell Line: DU145 cell Concentration: 2, 5, 10, and 20 μM Incubation Time: 12 h or 48 h Result: Reduced STAT3 phosphorylation by 90% at a concentration of 20 μM but not p-JAK2-Y1007/1008. Significantly reduced the amount of BCL-2 and BCL-xL, and induces BCL-xL PARP cleavage, the percentage of cells in G0/G1 phase decreased.
In Vivo	8-Epixanthatin (i.p., 50 mg/kg, 5 days per week for 25 days) 在 DU145 细胞的小鼠异种移植模型中，可以通过 STAT3 失活抑制肿瘤生长，小鼠肿瘤体积减少了40.1%，肿瘤重量减少了40.0%，肿瘤中 p-STAT3 水平显著降低[1]。
References	[1]. Yu-Jin Lee, et al. 8-Epi-xanthatin induces the apoptosis of DU145 prostate carcinoma cells through signal transducer and activator of transcription 3 inhibition and reactive oxygen species generation. Phytother Res. 2021 Mar;35(3):1508-1520.

Density	1.1±0.1 g/cm3
Boiling Point	444.3±45.0 °C at 760 mmHg
Molecular Formula	C₁₅H₁₈O₃
Molecular Weight	246.302
Flash Point	199.1±28.8 °C
Exact Mass	246.125595
LogP	1.58
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.528
Storage condition	2-8℃