8-Epixanthatin
Modify Date: 2024-01-09 14:14:00
8-Epixanthatin structure
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Common Name | 8-Epixanthatin | ||
|---|---|---|---|---|
| CAS Number | 30890-35-8 | Molecular Weight | 246.302 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 444.3±45.0 °C at 760 mmHg | |
| Molecular Formula | C15H18O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 199.1±28.8 °C | |
Use of 8-Epixanthatin8-Epixanthatin is a potential colchicine binding site inhibitor isolated from Xanthium chinese Mill. 8-Epixanthatin can inhibit the activation of STAT3, induce apoptosis, and has anti-tumor activity[1]. |
| Name | 8DFW6D5G55 |
|---|---|
| Synonym | More Synonyms |
| Description | 8-Epixanthatin is a potential colchicine binding site inhibitor isolated from Xanthium chinese Mill. 8-Epixanthatin can inhibit the activation of STAT3, induce apoptosis, and has anti-tumor activity[1]. |
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| Related Catalog | |
| In Vitro | 8-Epixanthatin(2-20 μM, 12 h) 可以以剂量依赖性方式抑制 DU145 细胞增殖和 DU145 细胞的 p-STAT3 水平，其 IC50 值为 3.2 μM[1]。 8-Epixanthatin可以通过诱导 DU145 癌细胞中 ROS 的产生抑制 STAT3 的激活和细胞增殖[1]。 Cell Proliferation Assay[1] Cell Line: DU145 cell Concentration: 2, 5, 10, and 20 μM Incubation Time: 12 h or 48 h Result: Reduced STAT3 phosphorylation by 90% at a concentration of 20 μM but not p-JAK2-Y1007/1008. Significantly reduced the amount of BCL-2 and BCL-xL, and induces BCL-xL PARP cleavage, the percentage of cells in G0/G1 phase decreased. |
| In Vivo | 8-Epixanthatin (i.p., 50 mg/kg, 5 days per week for 25 days) 在 DU145 细胞的小鼠异种移植模型中，可以通过 STAT3 失活抑制肿瘤生长，小鼠肿瘤体积减少了40.1%，肿瘤重量减少了40.0%，肿瘤中 p-STAT3 水平显著降低[1]。 |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 444.3±45.0 °C at 760 mmHg |
| Molecular Formula | C15H18O3 |
| Molecular Weight | 246.302 |
| Flash Point | 199.1±28.8 °C |
| Exact Mass | 246.125595 |
| LogP | 1.58 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Index of Refraction | 1.528 |
| Storage condition | 2-8℃ |
| 8DFW6D5G55 |
| 8-epi-Xanthatin |
| 2H-Cyclohepta[b]furan-2-one, 3,3a,4,7,8,8a-hexahydro-7-methyl-3-methylene-6-[(1E)-3-oxo-1-buten-1-yl]-, (3aR,7S,8aR)- |
| (3aR,7S,8aR)-7-Methyl-3-methylene-6-[(1E)-3-oxo-1-buten-1-yl]-3,3a,4,7,8,8a-hexahydro-2H-cyclohepta[b]furan-2-one |