1402452-15-6
1402452-15-6 structure
- Name: hSMG-1 inhibitor 11j
- Chemical Name: compound 11j [PMID: 23021994]
- CAS Number: 1402452-15-6
- Molecular Formula: C27H28ClN7O3S
- Molecular Weight: 566.074
- Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
- Create Date: 2018-06-11 07:24:22
- Modify Date: 2025-08-25 08:29:34
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hSMG-1 inhibitor 11j, a pyrimidine derivative, is a potent and selective inhibitor of hSMG-1, with an IC50 of 0.11 nM. hSMG-1 inhibitor 11j exhibits >455-fold selectivity for hSMG-1 over mTOR (IC50=50 nM), PI3Kα/γ (IC50=92/60 nM) and CDK1/CDK2 (IC50=32/7.1 μM). hSMG-1 inhibitor 11j can be used for the research of cancer[1].
| Name | compound 11j [PMID: 23021994] |
|---|---|
| Synonyms |
compound 11j [PMID: 23021994]
2-Chloro-N,N-diethyl-5-{[4-(2-{4-[(methylcarbamoyl)amino]phenyl}-4-pyridinyl)-2-pyrimidinyl]amino}benzenesulfonamide Benzenesulfonamide, 2-chloro-N,N-diethyl-5-[[4-[2-[4-[[(methylamino)carbonyl]amino]phenyl]-4-pyridinyl]-2-pyrimidinyl]amino]- |
| Description | hSMG-1 inhibitor 11j, a pyrimidine derivative, is a potent and selective inhibitor of hSMG-1, with an IC50 of 0.11 nM. hSMG-1 inhibitor 11j exhibits >455-fold selectivity for hSMG-1 over mTOR (IC50=50 nM), PI3Kα/γ (IC50=92/60 nM) and CDK1/CDK2 (IC50=32/7.1 μM). hSMG-1 inhibitor 11j can be used for the research of cancer[1]. |
|---|---|
| Related Catalog | |
| Target |
hSMG-1:0.11 nM (IC50) mTOR:50 nM (IC50) PI3Kγ:60 nM (IC50) PI3Kα:92 nM (IC50) GSKα:260 (IC50) GSKβ:330 (IC50) CDK2:7.1 μM (IC50) CDK1:32 μM (IC50) |
| In Vitro | hSMG-1 inhibitor 11j (0.3-3 μM; 6 h) significantly reduces UPF1 phosphorylation at 0.3 μM, and eliminates it at 1 μM in MDA 361 cells[1]. hSMG-1 inhibitor 11j inhibits MDA468 cell proliferation, with an IC50 of 75 nM[1]. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Molecular Formula | C27H28ClN7O3S |
| Molecular Weight | 566.074 |
| Exact Mass | 565.166260 |
| LogP | 4.38 |
| Index of Refraction | 1.640 |