1428862-32-1
1428862-32-1 structure
- Name: Usmarapride free base
- Chemical Name: GNQ25KYD72
- CAS Number: 1428862-32-1
- Molecular Formula: C21H29N5O2
- Molecular Weight: 383.487
- Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
- Create Date: 2018-06-21 18:47:22
- Modify Date: 2025-09-17 12:02:13
-
Usmarapride (SUVN-D4010) free base is a potent, selective, orally active and brain penetrant 5-HT4 receptor partial agonist (EC50=44 nM). Usmarapride (SUVN-D4010) free base can be used for the research of cognitive deficits associated with Alzheimer's disease[1].
| Name | GNQ25KYD72 |
|---|---|
| Synonyms |
1H-Indazole, 3-[5-[1-(3-methoxypropyl)-4-piperidinyl]-1,3,4-oxadiazol-2-yl]-1-(1-methylethyl)-
1-Isopropyl-3-{5-[1-(3-methoxypropyl)-4-piperidinyl]-1,3,4-oxadiazol-2-yl}-1H-indazole GNQ25KYD72 |
| Description | Usmarapride (SUVN-D4010) free base is a potent, selective, orally active and brain penetrant 5-HT4 receptor partial agonist (EC50=44 nM). Usmarapride (SUVN-D4010) free base can be used for the research of cognitive deficits associated with Alzheimer's disease[1]. |
|---|---|
| Related Catalog | |
| Target |
5-HT4 Receptor:44 nM (EC50) |
| In Vivo | Usmarapride (SUVN-D4010) (1-3 mg/kg; p.o.; Male Wistar rats 10-12 weeks old) free base attenuates the long-term memory deficits in object recognition test (ORT)[1]. Usmarapride (1, 3, and 10 mg/kg; p.o.) free base significantly reverses the scopolamine-induced amnesia[1]. Usmarapride free base shows a statistically significant effect at 3.0 mg/kg on both exploration time and recognition index[1]. Usmarapride (SUVN-D4010) free base shows good oral exposures, good bioavailability, and good brain exposures in rats[1]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 541.9±60.0 °C at 760 mmHg |
| Molecular Formula | C21H29N5O2 |
| Molecular Weight | 383.487 |
| Flash Point | 281.5±32.9 °C |
| Exact Mass | 383.232117 |
| LogP | 1.78 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.636 |