166526-99-4
166526-99-4 structure
- Name: 3-Hydroxy agomelatine
- Chemical Name: 3-Hydroxy Agomelatine
- CAS Number: 166526-99-4
- Molecular Formula: C15H17NO3
- Molecular Weight: 259.300
- Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
- Create Date: 2018-10-17 19:08:46
- Modify Date: 2024-01-02 15:48:01
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3-Hydroxy agomelatine is a metabolite of Agomelatine. 3-Hydroxy agomelatine is a 5-HT2C receptor antagonist with an IC50 of 3.2 μM and a Ki of 1.8 μM[1].
| Name | 3-Hydroxy Agomelatine |
|---|---|
| Synonyms |
N-[2-(3-Hydroxy-7-methoxy-1-naphthyl)ethyl]acetamide
Acetamide, N-[2-(3-hydroxy-7-methoxy-1-naphthalenyl)ethyl]- N-(2-(3-hydroxy-7-methoxynaphthalen-1-yl)ethyl)acetamide |
| Description | 3-Hydroxy agomelatine is a metabolite of Agomelatine. 3-Hydroxy agomelatine is a 5-HT2C receptor antagonist with an IC50 of 3.2 μM and a Ki of 1.8 μM[1]. |
|---|---|
| Related Catalog | |
| Target |
5-HT2C Receptor:3.2 μM (IC50) 5-HT2C Receptor:1.8 μM (Ki) |
| In Vitro | Agomelatine and S 21517 have moderately high affinities for 5-HT2C receptors (Ki = 0.21 μM and 0.13 μM, respectively). The metabolite 3-Hydroxy agomelatine (S 21540) has a 10-fold lower affinity (Ki = 1.8 μM). Agomelatine, S 21517 and 3-Hydroxy agomelatine (10-7-10-4 M) are antagonists at 5-HT2C receptors, with a rank order of efficacy as follows: S 21517>Agomelatine>3-Hydroxy agomelatine[1]. |
| In Vivo | Increasing doses (from 1.25 to 40 mg/kg, intraperitoneal injection) of 3-Hydroxy agomelatine (S 21540) does not affect the penile erections induced by mCPP and Ro 60-0175 in Wistar rat[1]. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 545.8±40.0 °C at 760 mmHg |
| Molecular Formula | C15H17NO3 |
| Molecular Weight | 259.300 |
| Flash Point | 283.9±27.3 °C |
| Exact Mass | 259.120850 |
| LogP | 1.53 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.606 |