202808-11-5

202808-11-5 structure

Name: MRZ 2-514
Chemical Name: MRZ 2-514
CAS Number: 202808-11-5
Molecular Formula: C₁₁H₆BrN₃O₃
Molecular Weight: 308.09
Catalog: Signaling Pathways Membrane Transporter/Ion Channel iGluR
Create Date: 2018-02-08 07:53:22
Modify Date: 2024-01-12 10:02:52
MRZ 2-514 is an antagonist of the strychnine-insensitive modulatory site of the NMDA receptor (glycineB), with Ki of 33 μM.

Name	MRZ 2-514

Description	MRZ 2-514 is an antagonist of the strychnine-insensitive modulatory site of the NMDA receptor (glycineB), with Ki of 33 μM.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease
Target	Ki: 33 μM (glycineB)[1]
In Vitro	MRZ 2-514 has IC50 values against peak AMPA-induced currents of 72.7 μM[1].
In Vivo	MRZ 2/514 has anticonvulsive action in the MES model in mice, and the effect is prolonged by probenecid[1].
References	[1]. Parsons CG, et al. Novel systemically active antagonists of the glycine site of the N-methyl-D-aspartate receptor: electrophysiological, biochemical and behavioral characterization. Journal of Pharmacology and Experimental Therapeutics (1997), 283(3), 1264-1275