DC Chemicals Limited
China
Product Name: KKL-35
Price: $1100.0/250mg $600.0/100mg $2100.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

865285-29-6

865285-29-6 structure

865285-29-6 structure

Name: KKL-35
Chemical Name: KKL-35
CAS Number: 865285-29-6
Molecular Formula: C₁₅H₉ClFN₃O₂
Molecular Weight: 317.702
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2018-06-26 10:16:57
Modify Date: 2024-02-01 07:39:41
KKL-35 is a trans-translation tagging reaction inhibitor with an IC50 of 0.9 µM.

Name	KKL-35
Synonyms	4-Chloro-N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]benzamide Benzamide, 4-chloro-N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]-

Description	KKL-35 is a trans-translation tagging reaction inhibitor with an IC50 of 0.9 µM.
Related Catalog	Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection
Target	IC50: 0.9 µM (trans-translation tagging reaction)[1]
In Vitro	KKL-35 exhibits broad-spectrum antibiotic activity. KKL-35 prevents growth of B. anthracis and M. smegmatis with minimum inhibitory concentration (MIC) values of less than 6 µM. KKL-35 inhibit trans-translation at some step before proteolysis of tagged proteins. KKL-35 inhibits tagging of DHFR-ns. A large amount of untagged DHFR is produced in reactions with the highest concentrations of KKL-35, indicating that KKL-35 does not inhibit translation. KKL-35 prevents growth of WT S. flexneri with a MIC of 6 µM, and addition of KKL-35 to a growing culture of S. flexneri stops growth. In an S. flexneri strain expressing ArfA and deleted for ssrA, addition of KKL-35 has little effect on viability or growth rate. KKL-35 inhibits the growth of E. coli ∆tolC, which is deficient in small molecule efflux, with an MIC of 0.3 µM[1].
In Vivo	Evidence suggest that the in vivo effects of KKL-35 are caused by inhibition of the release of nonstop translation complexes by trans-translation. KKL-35 inhibits trans-translation and prevents growth of S. flexneri strains that require trans-translation. The correlation between inhibition of trans-translation and growth is supported by genetic and pharmacological experiments showing that alternative mechanisms to release nonstop translation complexes relieve the growth suppression of KKL-35[1].
References	[1]. Ramadoss NS, et al. Small molecule inhibitors of trans-translation have broad-spectrum antibiotic activity. Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):10282-7.

Density	1.5±0.1 g/cm3
Molecular Formula	C₁₅H₉ClFN₃O₂
Molecular Weight	317.702
Exact Mass	317.036743
LogP	4.13
Index of Refraction	1.639

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
RIDADR	NONH for all modes of transport