Top Suppliers:I want be here

  • DC Chemicals Limited
  • China
  • Product Name: PROTO-1
  • Price: $400.0/10mg $1200.0/50mg $1680.0/100mg
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

312951-85-2

312951-85-2 structure
312951-85-2 structure
  • Name: PROTO-1
  • Chemical Name: PROTO-1
  • CAS Number: 312951-85-2
  • Molecular Formula: C17H19ClN4O2S
  • Molecular Weight: 378.876
  • Catalog: Research Areas Others
  • Create Date: 2018-05-25 00:24:17
  • Modify Date: 2024-01-11 13:51:02
  • PROTO-1 shows significant protection of hair cells, with HC50(concentration that would produce 50% hair cell survival) of 1 μM-10 μM (1 μM≤HC50≤10 μM).Target:PROTO-1 shows significant protection of hair cells over a broad range of neomycin concentrations, from 25 μM to 400 μM. Pretreatment with 1 and 10 μM PROTO-1 results in significant protection of hair cells exposed to 200 μM neomycin compared to neomycin alone. PROTO-1 protection against neomycin is tested at 4 mM neomycin and showed significant striolar.[2]

Name PROTO-1
Synonyms Thieno[2,3-c]pyridine-3-carboxamide, 2-[[[(4-chlorophenyl)amino]carbonyl]amino]-6-ethyl-4,5,6,7-tetrahydro-
2-{[(4-Chlorophenyl)carbamoyl]amino}-6-ethyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide
MFCD01923572
Description PROTO-1 shows significant protection of hair cells, with HC50(concentration that would produce 50% hair cell survival) of 1 μM-10 μM (1 μM≤HC50≤10 μM).Target:PROTO-1 shows significant protection of hair cells over a broad range of neomycin concentrations, from 25 μM to 400 μM. Pretreatment with 1 and 10 μM PROTO-1 results in significant protection of hair cells exposed to 200 μM neomycin compared to neomycin alone. PROTO-1 protection against neomycin is tested at 4 mM neomycin and showed significant striolar.[2]
Related Catalog
References

[1]. Rubel, et al. COMPOUNDS AND METHODS FOR PREVENTING, TREATING AND/OR PROTECTING AGAINST SENSORY HAIR CELL DEATH

[2]. Owens KN, et al. Identification of genetic and chemicalm modulators of zebrafish mechanosensory hair cell death. PLoS Genet. 2008 Feb 29;4(2):e1000020.

Density 1.4±0.1 g/cm3
Boiling Point 430.9±45.0 °C at 760 mmHg
Molecular Formula C17H19ClN4O2S
Molecular Weight 378.876
Flash Point 214.4±28.7 °C
Exact Mass 378.091736
LogP 4.30
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.698
Storage condition 2-8℃