160756-38-7
160756-38-7 structure
- Name: CNS-5161 hydrochloride
- Chemical Name: CNS-5161 hydrochloride
- CAS Number: 160756-38-7
- Molecular Formula: C16H19Cl2N3S2
- Molecular Weight: 388.378
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel iGluR
- Create Date: 2018-01-19 12:09:38
- Modify Date: 2024-01-11 09:18:49
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CNS-5161 hydrochloride is a novel NMDA ion-channel antagonist that interacts with the NMDA receptor/ion channel site to produce a noncompetitive blockade of the actions of glutamate.
| Name | CNS-5161 hydrochloride |
|---|---|
| Synonyms |
2-[2-Chloro-5-(methylsulfanyl)phenyl]-1-methyl-1-[3-(methylsulfanyl)phenyl]guanidine hydrochloride (1:1)
Guanidine, N''-[2-chloro-5-(methylthio)phenyl]-N-methyl-N-[3-(methylthio)phenyl]-, hydrochloride (1:1) |
| Description | CNS-5161 hydrochloride is a novel NMDA ion-channel antagonist that interacts with the NMDA receptor/ion channel site to produce a noncompetitive blockade of the actions of glutamate. |
|---|---|
| Related Catalog | |
| Target |
NMDA receptor/ion channel[1] |
| In Vitro | CNS-5161 (CNS 5161) is a novel and selective noncompetitive antagonist of the NMDA subset of glutamate receptors in the mammalian brain. CNS-5161 has potent inhibitory activity in vitro at the NMDA ion channel and is able to displace [3H] MK-801 binding with a Ki of 1.8 nM in synaptosomal membrane preparations from rat brain[1]. |
| In Vivo | In the neonatal rat NMDA excitotoxicity model in vivo, CNS-5161 (CNS 5161) protects against the necrotic effects of exogenous N-methyl-D-aspartate with an ED80 of 4 mg/kg by the intraperitoneal (i.p.) route. CNS-5161 also shows a 91% inhibition of audiogenic seizures in DBA/2 mice at 4 mg/kg i.p., and has a neuroprotective effect following hypoxix/ischaemic brain injury in neonatal rats[1]. |
| References |
| Molecular Formula | C16H19Cl2N3S2 |
|---|---|
| Molecular Weight | 388.378 |
| Exact Mass | 387.039734 |