1345445-57-9
1345445-57-9 structure
- Name: IQ-R
- Chemical Name: IQ-R
- CAS Number: 1345445-57-9
- Molecular Formula: C34H28N2O7
- Molecular Weight: 576.595
- Catalog: Research Areas Others
- Create Date: 2018-03-30 23:22:13
- Modify Date: 2025-08-27 02:19:42
-
IQ-R is a novel hypoxia-sensitive fluorescent probe, consisting of an indolequinone unit and a rhodol fluorophore.Target:IQ-R has good solubility in water and longer wavelength for absorption and emission, which are favorable for cellular bioimaging. While the fluorescence of rhodol in the IQ-R conjugate is quenched by the function of intramolecular indolequinone unit, it is restored under hypoxic conditions through the enzymatic one-electron reduction of IQ-R by NADPH: cytochrome P450 reductase to release the nonconjugated free rhodol. When administered to A549 cells, IQ-R is activated and reduced by endogenous reductase preferentially under hypoxic conditions, thereby visualizing hypoxic cancer cells by robust fluorescence.
| Name | IQ-R |
|---|---|
| Synonyms |
(5-Methoxy-1,2-dimethyl-4,7-dioxo-4,7-dihydro-1H-indol-3-yl)methyl 2-[6-(dimethylamino)-3-oxo-3H-xanthen-9-yl]benzoate
2-(6-dimethylamino-3-oxo-3H-xanthen-9-yl)-benzoic acid 5-methoxy-1,2-dimethyl-4,7-dioxo-4,7-dihydro-1H-indol-3-ylmethyl ester Benzoic acid, 2-[6-(dimethylamino)-3-oxo-3H-xanthen-9-yl]-, (4,7-dihydro-5-methoxy-1,2-dimethyl-4,7-dioxo-1H-indol-3-yl)methyl ester |
| Description | IQ-R is a novel hypoxia-sensitive fluorescent probe, consisting of an indolequinone unit and a rhodol fluorophore.Target:IQ-R has good solubility in water and longer wavelength for absorption and emission, which are favorable for cellular bioimaging. While the fluorescence of rhodol in the IQ-R conjugate is quenched by the function of intramolecular indolequinone unit, it is restored under hypoxic conditions through the enzymatic one-electron reduction of IQ-R by NADPH: cytochrome P450 reductase to release the nonconjugated free rhodol. When administered to A549 cells, IQ-R is activated and reduced by endogenous reductase preferentially under hypoxic conditions, thereby visualizing hypoxic cancer cells by robust fluorescence. |
|---|---|
| Related Catalog | |
| References |
| Density | 1.3±0.0 g/cm3 |
|---|---|
| Boiling Point | 879.8±0.0 °C at 760 mmHg |
| Molecular Formula | C34H28N2O7 |
| Molecular Weight | 576.595 |
| Flash Point | 485.9±0.0 °C |
| Exact Mass | 576.189636 |
| LogP | 5.22 |
| Vapour Pressure | 0.0±0.0 mmHg at 25°C |
| Index of Refraction | 1.652 |
| Storage condition | 2-8℃ |