1181083-81-7

1181083-81-7 structure

Name: CLP-290
Chemical Name: 5-Fluoro-2-{(Z)-[4-oxo-2-(tetrahydro-1(2H)-pyridazinyl)-1,3-thiazol-5(4H)-ylidene]methyl}phenyl 1-pyrrolidinecarboxylate
CAS Number: 1181083-81-7
Molecular Formula: C₁₉H₂₁FN₄O₃S
Molecular Weight: 404.458
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Potassium Channel
Create Date: 2018-01-29 01:30:09
Modify Date: 2024-01-09 23:05:08
CLP290 is an orally available activator of the neuron-specific K+-Cl− cotransporter KCC2, displays potential for treatment of a wide range of neurological and psychiatric indications. CLP290 can significantly lower blood arginine-vasopressin (AVP) and glucose levels in STZ rats[1][2].

Name	5-Fluoro-2-{(Z)-[4-oxo-2-(tetrahydro-1(2H)-pyridazinyl)-1,3-thiazol-5(4H)-ylidene]methyl}phenyl 1-pyrrolidinecarboxylate
Synonyms	MFCD28166314 1-Pyrrolidinecarboxylic acid, 5-fluoro-2-[(Z)-[4-oxo-2-(tetrahydro-1(2H)-pyridazinyl)-5(4H)-thiazolylidene]methyl]phenyl ester 5-Fluoro-2-{(Z)-[4-oxo-2-(tetrahydro-1(2H)-pyridazinyl)-1,3-thiazol-5(4H)-ylidene]methyl}phenyl 1-pyrrolidinecarboxylate

Description	CLP290 is an orally available activator of the neuron-specific K+-Cl− cotransporter KCC2, displays potential for treatment of a wide range of neurological and psychiatric indications. CLP290 can significantly lower blood arginine-vasopressin (AVP) and glucose levels in STZ rats[1][2].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
Target	KCC2[1]
References	[1]. Ferrini F, et al. Enhancing KCC2 function counteracts morphine-induced hyperalgesia. Sci Rep. 2017 Jun 20;7(1):3870. [2]. Gagnon M, et al. Chloride extrusion enhancers as novel therapeutics for neurological diseases. Nat Med. 2013 Nov;19(11):1524-8. [3]. Kim YB, et al. Excitatory GABAergic Action and Increased Vasopressin Synthesis in Hypothalamic Magnocellular Neurosecretory Cells Underlie the High Plasma Level of Vasopressin in Diabetic Rats. Diabetes. 2018 Mar;67(3):486-495.