116759-35-4

116759-35-4 structure

Name: Nexopamil racemate
Chemical Name: Nexopamil racemate
CAS Number: 116759-35-4
Molecular Formula: C₂₄H₄₀N₂O₃
Molecular Weight: 404.586
Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
Create Date: 2018-01-09 05:21:05
Modify Date: 2025-08-25 19:44:05
Nexopamil racemate is the racemate of Nexopamil. Nexopamil is a combined Ca2+/5-HT2 antagonist on thrombus formation in vivo and on platelet aggregation in vitro.

Name	Nexopamil racemate
Synonyms	Benzeneacetonitrile, α-[3-(hexylmethylamino)propyl]-3,4,5-trimethoxy-α-(1-methylethyl)- 5-[Hexyl(methyl)amino]-2-isopropyl-2-(3,4,5-trimethoxyphenyl)pentanenitrile

Description	Nexopamil racemate is the racemate of Nexopamil. Nexopamil is a combined Ca2+/5-HT2 antagonist on thrombus formation in vivo and on platelet aggregation in vitro.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Cardiovascular Disease
Target	Ca2+/5-HT2[1]
In Vitro	Serotonin-induced platelet aggregation in dog platelet-rich plasma (PRP) in vitro is most potently inhibited by Nexopamil (IC50 81 nM) [1].
In Vivo	Nexopamil (0.05 mg/kg) completely abolishes cyclic flow reductions (CFRs) during the first 30 min after application without significantly altering hemodynamics[1].
References	[1]. Kirchengast M, et al. Inhibition by the combined Ca2+ and 5-HT2 receptor antagonist nexopamil (LU 49938) of intracoronary thrombus formation in a canine model of arterial stenosis and intimal damage. J Cardiovasc Pharmacol. 1993 Nov;22(5):687-94.